Decoding the Gurus cover image

Decoding the Gurus

Andrew Huberman and Peter Attia: Self-enhancement, supplements & doughnuts?

Nov 9, 2023
Dr. Peter Attia and Dr. Andrew Huberman discuss the life-extending properties of Metformin, week-long starvation regimes, self-dosing experimental treatments, and the controversy surrounding the benefits of Metformin in the longevity community. They also explore cultural differences in therapy, analyzing research papers, reading scientific papers, the cognitive enhancing effects of nicotine, the influence of belief on medication effectiveness, limitations in research studies, and self-experimentation in the health industry.
03:12:46

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Quick takeaways

  • The study re-evaluates the life-extending properties of Metformin and highlights the need for further investigation.
  • Metformin alters ATP production and glucose output but requires more research for a complete understanding.

Deep dives

The importance of reassessing the evidence of a survival advantage in type 2 diabetics treated with Metformin

A retrospective cohort study published last fall re-examines the claim that Metformin has life-extending properties. The original study in 2014 showed a 15% relative reduction in all-cause mortality for those on Metformin. However, the re-assessed study highlights limitations in the methodology, such as informative censoring, and questions the initial findings. The results indicate a difference of less than one year of life per 1,000 patient years studied, emphasizing the need for further investigation.

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