Nature Podcast

How a key Alzheimer's gene wreaks havoc in the brain

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Nov 16, 2022
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ANECDOTE

NASA's Artemis 1 Test Flight

  • NASA launched the huge Space Launch System rocket carrying the Orion capsule in an uncrewed test mission.
  • The capsule will orbit the Moon for 26 days before returning to Earth for splashdown off California.
INSIGHT

How ApoE4 Affects Alzheimer's

  • The Alzheimer's risk gene ApoE4 disrupts cholesterol management in oligodendrocytes.
  • This leads to defective myelin sheaths, which may explain cognitive deficits in Alzheimer's patients.
ADVICE

Target Cholesterol to Rescue Myelination

  • Reducing cholesterol accumulation in oligodendrocytes can rescue myelination abnormalities.
  • The drug cyclodextrin improved memory function in an Alzheimer's mouse model, showing therapeutic potential.
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