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How a key Alzheimer's gene wreaks havoc in the brain

Nature Podcast

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Alzheimer's Disease - Is This a Cause of the Accumulating Cholesterol?

The protein ApoE codes for can be trafficked out of the cell where it's made and affect other nearby cells. If this ApoE4 linked myelination defect appears before clinical diagnosis, that might indicate this is part of the root cause of Alzheimer's disease rather than an exacerbating factor. But as well as being excited by the findings, Karl says there are some things still to be clarified.

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