Episode #333. What does cholesterol have to do with dementia? Learn how to protect your brain health in the long term with this information you should be considering from your twenties and thirties. From cutting-edge science on cholesterol metabolism to fourteen key risk factors for dementia, we break down what you can do now to reduce your risk of cognitive decline later.
In this episode, I’m joined by two renowned experts, Dr Kellyann Niotis and Dr Thomas Dayspring. Together, we explore the connection between cholesterol and dementia, personalised prevention strategies, and how making lifestyle changes today can safeguard your brain for the future.
Specifically, we discuss:
- Intro (00:00)
- Cardiology Meets Neurology: Understanding the Connection (07:53)
- Dementia and Neurodegenerative Diseases: A Comprehensive Overview (13:26)
- Recognizing Early Dementia Signs and Risk Factors (21:43)
- Lipoproteins and Brain Health: The Crucial Link (32:36)
- ApoB vs ApoE: Comparing Apoprotein Functions in Neurological Health (44:24)
- APOE4 Carriers: Potential Therapeutic Approaches (01:00:30)
- ApoA1 and HDL: Their Role in Dementia Prevention (01:03:27)
- Genetic Testing for Dementia: Understanding APOE4 Implications (01:13:19)
- APOE4 Gene: Impact on Dementia Risk and Brain Health (01:17:58)
- Desmosterol's Role in Maintaining Brain Health (01:20:56)
- LDL Cholesterol: A Key Factor in Dementia Risk Assessment (01:34:05)
- APOE4: Comparing Single vs. Double Copy Risk Factors (01:39:15)
- Omega-3 Fatty Acids: Essential Nutrients for Brain Health (01:38:49)
- LDL Cholesterol Levels: Assessing Low vs. High Risk for Dementia (01:56:50)
- Key Takeaways: Preventive Neurology and Future Research Directions (02:00:10)
Connect with Dr Kellyann Niotis at https://drkellyannniotis.com/ and discover research and resources at https://ind.org/. Connect with Dr Thomas Dayspring on Twitter/X or LinkedIn, and listen to his past appearances on The Proof here.
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Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
The Proof with Simon Hill 
