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The Dr. Gabrielle Lyon Show
You Can Reverse Aging with Muscle | Kevin Murach PhD
Jan 9, 2024
01:29:27
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Kevin Murach, Exercise Physiology and Human Bioenergetics expert, discusses topics such as Yamanaka factors, DNA methylation, exercise-induced changes in muscle, and the impact of exercise on reversing aging. They explore the unique aspects of skeletal muscle aging, the connection between exercise and epigenetic changes, and the role of DNA methylation in skeletal muscle adaptation. They also touch on the importance of blood work, effective training protocols, and the potential benefits of creating epigenetic changes through exercise. Insights from a mouse study on exercise and aging reversal are discussed, along with the impact of nutrition on DNA methylation and skeletal muscle.
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Quick takeaways
- Resistance exercise can induce the Yamanaka factors, leading to age reversal in muscle.
- Regular exercise, especially resistance training, can positively impact methylation age and promote healthy aging.
Deep dives
Yamanaka factors and exercise adaptation
The Yamanaka factors are a set of transcription factors that can reprogram cells and revert them back to a pluripotent stem cell state. These factors, particularly the MICK factor, can be induced with exercise, with resistance exercise showing a higher response. The induction of these factors is transient and goes back to baseline relatively quickly. While the specific dose of exercise to induce these factors is still unknown, research suggests that resistance exercise may be more effective. It is important to note that MICK is an onco gene, and its sustained activation could be detrimental. Aging muscle shows changes in the epigenetic profile, including DNA methylation. DNA methylation refers to the addition or removal of methyl groups to specific nucleotides in the DNA, influencing gene expression. Studying DNA methylation in the context of aging and exercise can help understand how genes are accessed and how exercise adaptation occurs over the lifespan. Steve Horvath is a notable researcher in the field of DNA methylation and aging. While there is limited research on biomarkers in the blood directly related to muscle methylation, other biomarkers may provide insights into the epigenetic changes occurring in the muscle.
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