The Dr. Gabrielle Lyon Show
Dr. Gabrielle Lyon
The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are the primary focus. The goal of this show is to provide you with a framework for navigating the health and wellness space and, most importantly, being the champion of your own life. Guests include highly trustworthy professionals that bring both the art and science of wellness aspects that are both physical and mental. Dr. Gabrielle Lyon is a Washington University fellowship-trained physician who serves the innovators, mavericks, and leaders in their fields, as well as working closely with the Special Operations Military. She is the founder of the Institute of Muscle-Centric Medicine® and serves patients worldwide.
Episodes
Mentioned books
44 snips
Jan 13, 2026 • 1h 35min
Willpower vs. Systems: Why Your Diet Fails & How to Fix Your Relationship w/ Food | Sohee Carpenter
Sohee Carpenter, a sports scientist and PhD with a personal journey through eating disorders, brings her expertise to discuss the intersection of psychology and food habits. She unpacks the myth that willpower alone leads to diet success, emphasizing instead the importance of designing effortless, healthy habits. Sohee challenges common fitness beliefs, such as the need for heavy lifting, and shares evidence-based strategies like 'habit stacking' to promote sustainable change. Her insights highlight that mental health and minor adjustments pave the way for long-term success.
5 snips
Jan 6, 2026 • 1h 24min
The Gut-Muscle-Immune Axis: How Mitophagy Rewires Your Body for Longevity
Dr. Anurag Singh, a physician-researcher and Chief Medical Officer at Timeline, shares his insights into groundbreaking research on mitophagy and the gut-muscle-immune axis. He reveals how mitophagy enhances immune cell efficiency and discusses the decline of naive CD8 T cells with age. Dr. Singh explains the benefits of urolithin A for mitochondrial health and its remarkable effects on immune function and longevity. Tune in to discover how exercise and dietary strategies can optimize your cellular health!
23 snips
Dec 30, 2025 • 2h 30min
The Joint Health Blueprint: Preventing Arthritis, Frozen Shoulder, and Bone Loss as You Age
Dr. Gerard, an orthopedic and sports medicine specialist, and Dr. Jocelyn Wittstein, a bone health expert, share invaluable insights on joint and tendon health. They discuss the importance of progressive overload for tendons, impact training for osteoporosis prevention, and the hormonal connections to conditions like frozen shoulder. Dr. Wittstein highlights the higher arthritis risk women face post-menopause, while Dr. Gerard explores the intricacies of tendinopathy and effective recovery strategies.
5 snips
Dec 23, 2025 • 1h 3min
Hormone Replacement Therapy Decoded: Why the FDA Removed the Blackbox Warning on HRT
In this engaging discussion, Gabrielle Lyon, a leading expert in muscle-centric medicine, unpacks the recent FDA change to hormone replacement therapy (HRT) and its implications for menopause care. She addresses the importance of accurate hormone testing and the safety of testosterone for women. The conversation reveals the cognitive and physical benefits of balanced hormones, highlights testosterone's positive effects on energy and libido, and clarifies who should avoid HRT. Nick prompts deeper exploration into these critical health topics throughout.
4 snips
Dec 16, 2025 • 1h 27min
Dr. Jen Ashton on Unimaginable Loss, Mental Health, and Post-Traumatic Growth
Dr. Jen Ashton, a board-certified OB-GYN and medical correspondent, shares her journey through unimaginable loss following her husband’s tragic suicide. She opens up about the shock and the vital role her children played in her healing. Discussing mental health, Ashton highlights how resistance training became her lifeline post-trauma. She also addresses the misinformation around menopause care and GLP-1 medications, advocating for a nuanced approach. The conversation emphasizes resilience and the importance of prioritizing mental wellbeing alongside physical health.
8 snips
Dec 9, 2025 • 1h 3min
STOP Inflaming Your Body: The #1 Enemy to Egg Quality and Conception
Dr. Natalie Crawford, a double board-certified fertility doctor with a nutrition background, dives deep into the rising infertility crisis. She emphasizes the alarming role of inflammation in fertility, debunking myths that age alone impacts egg quality. Listeners learn crucial lifestyle changes that enhance fertility, including the significance of sleep, diet, and toxin reduction. Natalie also highlights the importance of comprehensive thyroid screening and practical methods to optimize reproductive health, making this discussion a must-listen for anyone interested in conception.
34 snips
Dec 2, 2025 • 55min
Carbs vs. Protein: Which Macronutrient Is Actually More Dangerous to Overconsume?
Nick Barringer, a nutrition and performance expert with a doctorate in kinesiology, joins the discussion on the dangers of excessive carbohydrate intake. They delve into how processed carbs significantly contribute to obesity and metabolic issues in the U.S. Barringer and Dr. Lyon highlight the importance of a balanced 1:1 protein-to-carb ratio and practical meal planning. They also explore strategies for families to reduce processed carbs at home and emphasize the superior nutrient profile of animal protein over plant-based sources, especially for those over 40.
43 snips
Nov 25, 2025 • 1h 44min
Over 70 and Shredded: The Guide to Building Muscle at Any Age | Michelle & Joan MacDonald
In this engaging conversation, Michelle MacDonald, a Certified Strength and Conditioning Specialist and founder of The Wonderwomen, teams up with her inspiring mother, Joan MacDonald, who began her fitness journey at 71. They discuss how age is no barrier to building muscle and share Joan's remarkable transformation story. Michelle also opens up about her struggles with eating disorders and the importance of mindset in fitness. Together, they emphasize resistance training for health, practical exercises for beginners, and the non-negotiable pillars of successful coaching.
106 snips
Nov 18, 2025 • 1h 39min
TRT: Your Complete Guide to Safe Dosing, Risks, and Boosting Longevity
Dr. Abraham Morgentaler, a leading urologist and testosterone researcher, challenges conventional beliefs about testosterone's role in aging and prostate health. He reveals that aging alone isn't to blame for low testosterone; obesity often plays a significant role. He emphasizes the importance of checking free testosterone levels over total testosterone. The discussion also highlights risks tied to unregulated influencer advice on testosterone use, linking erectile dysfunction to broader health issues and advocating for lifestyle changes to improve sexual function.
10 snips
Nov 11, 2025 • 1h 27min
Neuroscientist Explains MDMA and The Science of Social Connection | Dr. Ben Rein Ph.D.
Dr. Ben Rein, a neuroscientist and author of "Why Brains Need Friends," delves into the fascinating world of social connection and the neurobiology of empathy. He discusses how loneliness can be as harmful as smoking and the therapeutic benefits of MDMA for PTSD. The conversation explores ketamine’s alternative effects, the dangers of digital interactions on empathy, and the surprising role of Botox in emotional expression. Rein also highlights practical tips for enhancing likability, emphasizing the biological importance of social bonds for overall brain health.
