

The Dr. Gabrielle Lyon Show
Dr. Gabrielle Lyon
The Dr. Gabrielle Lyon Show promotes a healthy world, and in order to have a healthy world, we must have transparent conversations. This show is dedicated to such conversations as the listener; your education, understanding, strength, and health are the primary focus. The goal of this show is to provide you with a framework for navigating the health and wellness space and, most importantly, being the champion of your own life. Guests include highly trustworthy professionals that bring both the art and science of wellness aspects that are both physical and mental. Dr. Gabrielle Lyon is a Washington University fellowship-trained physician who serves the innovators, mavericks, and leaders in their fields, as well as working closely with the Special Operations Military. She is the founder of the Institute of Muscle-Centric Medicine® and serves patients worldwide.
Episodes
Mentioned books

Dec 30, 2025 • 2h 30min
The Joint Health Blueprint: Preventing Arthritis, Frozen Shoulder, and Bone Loss as You Age
Pre-Order The Forever Strong PLAYBOOK and receive exclusive bonuses: https://drgabriellelyon.com/playbook/Want ad-free episodes, exclusives and access to community Q&As? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comIf you are only focusing on building muscle, you are missing half the equation for long-term mobility. In this mashup episode, Dr. Gabrielle Lyon brings together top orthopedic experts to discuss the critical importance of joint and tendon health.While muscle develops relatively quickly, your tendons and ligaments can take 6 to 9 months to fully adapt to a new training stimulus. This gap is where most injuries happen. We dive deep into the biological mechanics of tendons, the"athletic accommodation timeline," and why you must progressively overload your connective tissue—not just your muscle bellies.You will learn:The Menopause Connection: Why women face a 30% higher risk of arthritis and rapid bone loss after age 50, and the role of estrogen in joint inflammation.Osteoporosis Prevention: Why high-impact "flight" exercises (jumping) are more effective for bone density than traditional lifting alone.The Frozen Shoulder Mystery: How to identify the warning signs and why this condition is often linked to hormonal shifts rather than trauma.Injury Recovery & Prehab: The truth about PRP, needle tenotomy, and the "anti-fragility" mindset needed to build a resilient body.The History of Muscle: How ancient Greek views of "pneuma" and the "gift of strength" shaped our modern misunderstanding of movement.Stop training until you break. Learn how to track your progress, prioritize stability over raw mobility, and design a life built for anti-fragility.0:00 - The Gap Between Muscle and Tendon Adaptation 1:32 - What Are Tendons? Visco-Elasticity and Force Dissipation 4:36 - The Rotator Cuff: Stabilizing the "Golf Ball on a Tee" 6:40 - The Athletic Accommodation Timeline: Why 6-9 Months Matters 8:36 - Progressive Overload for Connective Tissue, Not Just Muscle 11:36 - GLP-1s and Bone Health: Does Ozempic Increase Fracture Risk? 14:34 - Preventing Osteoporosis: The Power of Impact Training 18:15 - Bisphosphonates vs. Mechanical Loading for Bone Quality 21:10 - The Hidden History of Muscle: From Galen to Ancient Greece 26:48 - The Myth of "Pneuma" and the Soul in the Muscle 30:55 - Supercompensation: The "Gift from Zeus" in Performance 36:35 - Defining Impact Exercise: Why "Flight" is Better for Bones 39:48 - Building Your Base: Why Bone Health is Won Before Age 30 42:38 - Oral Contraceptives and Peroperative Blood Clot Risks 45:21 - The Hard Truth: How Nicotine Destroys Orthopedic Healing 47:55 - Testosterone and Muscle Mass vs. Bone Density in Women 51:41 - Relative Energy Deficiency in Sport (RED-s) and Stress Fractures 55:53 - Long-Term Menopause Consequences: Mobility and Hip Fractures 1:01:58 - Tendinopathy Treatments: Needle Tenotomy, 10X, and PRP 1:07:26 - Full Thickness vs. Incomplete Tendon Tears 1:12:05 - Prehab is Real: The Push-Up with a Plus and Skater Squats 1:13:58 - The Biomechanics of the Gate Cycle & Pelvic Stability 1:17:31 - Medications that Destroy Tendons: Fluoroquinolones & Statins 1:20:02 - Corticosteroids: Balancing Short-Term Relief with Repair Issues 1:24:12 - Nutrition for Joint Health: Collagen, Vitamin C, and Leucine 1:27:11 - Thyroid and Sex Hormone Influence on Tendon Metabolism 1:31:50 - The "Menopause Arthritis" Phenomenon 1:54:04 - Mobility vs. Stability: The 2x2 Evaluation Table 2:11:06 - Zone 2 vs. HIIT: Raising the Ceiling of Human Performance 2:24:21 - Anti-Fragility: Using Stressors to Get StrongerThank you to our sponsors: PaleoValley - Get 15% off automatically at https://paleovalley.com/DRLYON OneSkin - Get 15% off with the code DRLYON – https://www.oneskin.coBranch Basics - 15% off and free shipping on the Starter Kit when you use code DRLYON at BranchBasics.com/DRLYONPIQUE - Get 20% off for life + a complimentary gift Piquelife.com/DRLYONFind Dr. Jocelyn Wittstein at: Duke Health - https://www.dukehealth.org/find-docto... Instagram - @jocelyn_wittstein_md The Complete Bone and Joint Health Plan - Find it at Amazon and Barnes & Noble Find Gerard D'Onofrio, MD Web: https://www.summithealth.com/doctors/provider/1376049130 Linked In: linkedin.com/in/gerarddonofrio27 Find Dr. Gabrielle Lyon at: Instagram:@drgabriellelyon TikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube: youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonApply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/Join my weekly newsletter – https://institute-for-muscle-centric-medicine.ck.pagePre-order my new book - https://www.amazon.com/exec/obidos/ASIN/1668085623 Disclaimers: This episode includes paid sponsorships. The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

5 snips
Dec 23, 2025 • 1h 3min
Hormone Replacement Therapy Decoded: Why the FDA Removed the Blackbox Warning on HRT
In this engaging discussion, Gabrielle Lyon, a leading expert in muscle-centric medicine, unpacks the recent FDA change to hormone replacement therapy (HRT) and its implications for menopause care. She addresses the importance of accurate hormone testing and the safety of testosterone for women. The conversation reveals the cognitive and physical benefits of balanced hormones, highlights testosterone's positive effects on energy and libido, and clarifies who should avoid HRT. Nick prompts deeper exploration into these critical health topics throughout.

4 snips
Dec 16, 2025 • 1h 27min
Dr. Jen Ashton on Unimaginable Loss, Mental Health, and Post-Traumatic Growth
Dr. Jen Ashton, a board-certified OB-GYN and medical correspondent, shares her journey through unimaginable loss following her husband’s tragic suicide. She opens up about the shock and the vital role her children played in her healing. Discussing mental health, Ashton highlights how resistance training became her lifeline post-trauma. She also addresses the misinformation around menopause care and GLP-1 medications, advocating for a nuanced approach. The conversation emphasizes resilience and the importance of prioritizing mental wellbeing alongside physical health.

8 snips
Dec 9, 2025 • 1h 3min
STOP Inflaming Your Body: The #1 Enemy to Egg Quality and Conception
Dr. Natalie Crawford, a double board-certified fertility doctor with a nutrition background, dives deep into the rising infertility crisis. She emphasizes the alarming role of inflammation in fertility, debunking myths that age alone impacts egg quality. Listeners learn crucial lifestyle changes that enhance fertility, including the significance of sleep, diet, and toxin reduction. Natalie also highlights the importance of comprehensive thyroid screening and practical methods to optimize reproductive health, making this discussion a must-listen for anyone interested in conception.

33 snips
Dec 2, 2025 • 55min
Carbs vs. Protein: Which Macronutrient Is Actually More Dangerous to Overconsume?
Nick Barringer, a nutrition and performance expert with a doctorate in kinesiology, joins the discussion on the dangers of excessive carbohydrate intake. They delve into how processed carbs significantly contribute to obesity and metabolic issues in the U.S. Barringer and Dr. Lyon highlight the importance of a balanced 1:1 protein-to-carb ratio and practical meal planning. They also explore strategies for families to reduce processed carbs at home and emphasize the superior nutrient profile of animal protein over plant-based sources, especially for those over 40.

43 snips
Nov 25, 2025 • 1h 44min
Over 70 and Shredded: The Guide to Building Muscle at Any Age | Michelle & Joan MacDonald
In this engaging conversation, Michelle MacDonald, a Certified Strength and Conditioning Specialist and founder of The Wonderwomen, teams up with her inspiring mother, Joan MacDonald, who began her fitness journey at 71. They discuss how age is no barrier to building muscle and share Joan's remarkable transformation story. Michelle also opens up about her struggles with eating disorders and the importance of mindset in fitness. Together, they emphasize resistance training for health, practical exercises for beginners, and the non-negotiable pillars of successful coaching.

102 snips
Nov 18, 2025 • 1h 39min
TRT: Your Complete Guide to Safe Dosing, Risks, and Boosting Longevity
Dr. Abraham Morgentaler, a leading urologist and testosterone researcher, challenges conventional beliefs about testosterone's role in aging and prostate health. He reveals that aging alone isn't to blame for low testosterone; obesity often plays a significant role. He emphasizes the importance of checking free testosterone levels over total testosterone. The discussion also highlights risks tied to unregulated influencer advice on testosterone use, linking erectile dysfunction to broader health issues and advocating for lifestyle changes to improve sexual function.

10 snips
Nov 11, 2025 • 1h 27min
Neuroscientist Explains MDMA and The Science of Social Connection | Dr. Ben Rein Ph.D.
Dr. Ben Rein, a neuroscientist and author of "Why Brains Need Friends," delves into the fascinating world of social connection and the neurobiology of empathy. He discusses how loneliness can be as harmful as smoking and the therapeutic benefits of MDMA for PTSD. The conversation explores ketamine’s alternative effects, the dangers of digital interactions on empathy, and the surprising role of Botox in emotional expression. Rein also highlights practical tips for enhancing likability, emphasizing the biological importance of social bonds for overall brain health.

54 snips
Nov 4, 2025 • 1h 20min
Sex Therapist explains The Science-Backed Guide to a Better Sex Life | Marianne Brandon
Marianne Brandon, a licensed clinical psychologist and expert in sex therapy, shares insights on modern intimacy challenges. She discusses how technology, from AI to VR, creates a mismatch with our primal needs. The conversation highlights stress as a libido killer, the differences in male and female desire, and the unexpected impacts of digital intimacy on relationships. Marianne also addresses solutions for sexual wellness, the role of masturbation in partnered enjoyment, and the importance of open discussions about tech risks for future generations.

26 snips
Oct 28, 2025 • 1h 13min
The Menstrual Cycle DECODED: Fertility, PCOS, and the New Science of Hormones
Dr. Heidi, a reproductive physiologist renowned for her pioneering work on ovarian cycles and menopause, shares fascinating insights into female reproductive health. Discover how obesity and nutrition impact ovarian function and fertility. Dr. Heidi explains the mysteries of follicle waves and their role in ovulation, debunks common dietary myths regarding PCOS, and discusses the potential of ovarian morphology as a biomarker for health. With a focus on actionable science, this conversation empowers women to understand their bodies better.


