Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context.

00:32 Mancini interview
02:26 Anticholinergic burden method of action
02:58 Balancing the impact of side effects in schizophrenia treatment
04:52 Limitations
05:34 The need for further studies
05:59 Clinical implications
06:32 Further research
07:01 Trials needed
07:54 Kalin interview
08:03 Mancini et al.
11:23 Tiihonen et al.
13:43 Zhou et al.
16:28 Omlor et al.
18:51 Orhan et al.

Transcript

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April 2025: Anticholinergic Burden and Cognitive Function in Psychosis: A Systematic Review and Meta-Analysis