In this insightful discussion, Dr. Valentina Mancini, a researcher at Oxford University, delves into the effects of anticholinergic burden on cognition among schizophrenia patients, emphasizing the importance of medication management. She highlights the balance needed between medication benefits and cognitive impairments and calls for further rigorous studies. Dr. Ned Kalin, Editor-in-Chief of The American Journal of Psychiatry, contextualizes recent research findings, reinforcing the need for innovative treatment strategies to optimize patient care.