Nutrition Facts with Dr. Greger More on Boosting NAD+
Sep 18, 2025
Delve into the intriguing world of NAD+ boosters and discover the battle between NMN and NR. Learn about the limited benefits shown in human trials, including mixed exercise outcomes. Explore the potential risks of lesser-known supplements like tryptophan and the challenges of oral NAD forms. The discussion highlights safety concerns and product mislabeling, revealing a complex landscape of NAD+ supplementation. Throughout, the emphasis is on understanding how these substances interact with our bodies.
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NMN vs NR: Similar Yet Unsettled
- NMN and NR both raise NAD in animals and humans but haven't been compared directly head-to-head in people.
- NMN may be more stable in blood and is a direct NAD precursor, but cell entry is debated due to its phosphate group.
NMN Cell Entry Is Controversial
- NMN carries a phosphate that may prevent cell membrane passage, requiring conversion to NR to enter cells.
- A proposed NMN transporter in mouse intestines could allow direct NMN uptake, but evidence remains controversial.
Human Evidence For NMN Is Limited
- NMN shows many rodent healthspan benefits but no demonstrated lifespan extension in mammals yet.
- Human trials are few and have not shown convincing broad benefits beyond transient blood NAD raises.
