#62: Diabetes | CO2 | Mineral Balancing? | Coenzyme Q10 | Cognitive Capture | Parathyroid Hormone with Georgi Dinkov
Jul 11, 2021
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Topics include effects of intense training on mitochondrial function, relationship between renin-angiotensin-aldosterone system and parathyroid hormone, impact of dietary PUFA on heart health, PUFA's effect on blood glucose control in diabetes, legal battle over copyright laws in scientific works distribution, and Alexandra's influence on science accessibility.
Polyunsaturated fats can increase blood pressure, saturated fats show resilience, decrease in sodium excretion.
Coenzyme Q10 reverses mitochondrial damage caused by Poofs, naringenin protects heart from oxidative stress.
Flavones like naringenin act as anti-estrogens, enhance androgenic effects, potential product combining flavones/flavanones.
Development of serotonin antagonists for cancer treatment, new anti-serotonin agents for migraines, nuanced dosage recommendations.
Deep dives
Effect of Poofs on Blood Pressure
A study showed that a 20% increase in polyunsaturated fats (Poofs) in the diet led to a 20-30% increase in blood pressure compared to a high saturated fat diet. The rats on the saturated fat diet showed resilience to developing high blood pressure that they were genetically predisposed to. The rats on the high Poof diet had decreased sodium excretion from the cells, indicating a decrease in oxidative phosphorylation relation.
Mitochondrial Damage and Protection by Coenzyme Q10
Studies indicate that Poofs damage mitochondrial complexes, especially complexes I and IV. Supplementing with coenzyme Q10 can reverse some of this damage. Minor increase in Poof intake for four weeks increased heart fibrotic processes. Naringenin has been shown to protect the heart from Poof-induced damage by reducing reactive oxygen species.
Flavones and Flavanones as Phyto-Progestrogens
Flavones and flavanones like naringenin and apigenin are considered phyto-progestrogens, acting as anti-estrogens at the receptor level and aromatase inhibitors. They bind to the estrogen and progesterone receptors. Naringenin is the most potent aromatase inhibitor and shows potential androgenic effects by increasing dihydrotestosterone production.
Development of ID Labs' New Product
ID Labs is working on a product that combines flavones and flavanones, focusing on improving bioavailability and potency. One product version will contain methylated flavones and flavanones for increased effectiveness at lower dosages. Another version will include components that are heavily anti-estrogenic and androgenic, based on natural compounds found in nature.
Synthesis of Serotonin Antagonists
Serotonin antagonists like six methoxy-harmalane are being synthesized for potential cancer treatment, enhancing bioavailability and efficacy. Studies show promising results with lower dosages effectively treating cancer.
Exploring Migraine Treatments
New anti-serotonin agents, including Tropoxin, are being developed as potential migraine treatments without antihistamine side effects. Vitamin B2 (riboflavin) shows promise in aiding serotonin degradation, providing a natural alternative for migraine relief.
Usage Recommendations and Legal Constraints
Dosage recommendations are nuanced and individual-dependent, considering factors like health status and metabolisms. Legal restrictions prevent explicit dosing advice for lab-sold products, encouraging self-experimentation and collaborative forums for peer reviews and recommendations.
00:00 - Start, catch-up with Georgi, farming, covid death statistics, the Pentagon is gross
22:51 - Study finds intense training sessions temporarily impair mitochondrial function
34:03 - The interplay between the renin-angiotensin-aldosterone system and parathyroid hormone, sodium, CO2
42:40 - The effect of dietary PUFA on cation transport and hypertension in the rat
45:17 - COQ10 protects from aging-related oxidative stress and improves mitochondrial function in the heart of rats fed PUFA-rich diet, the difference between ubiquinone (oxidized) and ubiquinol (reduced), ROS
52:06 - Idealabs update, naringenin, apigenin
01:11:34 - PUFA impair blood glucose control in type 2 diabetic patients, hyperglycemia as the result of metabolic stress (not high carbohydrate intake), PUFA and ACTH
01:19:51 - Advanced age, but not anergy, is associated with altered serum polyunsaturated fatty acids levels
01:21:55 - Sci-Hub lawsuit, Alexandra Elbakyan is a science hero, Aaron Swartz
01:31:28 - Neuronal lipolysis participates in PUFA-meditated neural function and neurodegeneration
01:32:18 - Idealabs update, serotonin antagonist (tropoxin)
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