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307. GLP-1 Agonists, Fat Loss Biohacks & Hormone Optimisation With Dr. Kyle Gillet
Mar 24, 2025
Dr. Kyle Gillet, an expert in hormone optimization, dives deep into GLP-1 agonists and their surprising roles in weight loss and muscle growth. He discusses the intriguing differences between GLP-1 and metformin, as well as the benefits of emerging therapies like myostatin inhibitors. The conversation also highlights the impact of insulin sensitivity on athletic performance and the importance of protein intake for muscle health. Dr. Gillet even touches on the potential of methylene blue in enhancing performance and mood, making for a fascinating listen!
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Quick takeaways
- GLP-1 agonists show promising weight loss results and improved insulin sensitivity, especially for individuals with high body fat percentages.
- The delicate balance in GLP-1 dosing is crucial as higher doses can suppress appetite but may lead to muscle loss if mismanaged.
Deep dives
Growth of GLP-1 Agonists
Recent research indicates a significant increase in the use of GLP-1 agonists for weight management among overweight Americans. Studies reveal that nearly one-third to one-half of these individuals have experimented with medications such as semaglutide, often initiated through med spas or free trials. Although higher dosages of GLP-1, like 7.2 mg weekly, show only a minimal increase in weight loss compared to lower doses, they come with a greater risk of side effects. This information underscores the necessity for medical professionals to carefully consider the balance between dosage, efficacy, and patient tolerance.
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