Dr. Kyle Gillet, an expert in hormone optimization, dives deep into GLP-1 agonists and their surprising roles in weight loss and muscle growth. He discusses the intriguing differences between GLP-1 and metformin, as well as the benefits of emerging therapies like myostatin inhibitors. The conversation also highlights the impact of insulin sensitivity on athletic performance and the importance of protein intake for muscle health. Dr. Gillet even touches on the potential of methylene blue in enhancing performance and mood, making for a fascinating listen!
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High-Dose Semaglutide
Higher doses of semaglutide (e.g., 7.2mg) yield minimal extra weight loss (3%) compared to 2.4mg.
Side effects increase significantly with higher doses, based on year-long studies.
insights INSIGHT
GLP-1 Agonist Trial Prevalence
About one-third to one-half of overweight US adults have tried a GLP-1 agonist at least once.
This includes free samples or single doses, potentially explaining high trial numbers.
insights INSIGHT
GLP-1 and Muscle Loss
GLP-1 agonists can cause muscle loss when combined with a severe calorie deficit and insufficient protein.
However, at the right dose, most patients gain lean body mass while using GLP-1s.
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In this episode of the Boost Your Biology podcast, Lucas Aoun interviews Dr. Kyle Gillett, who shares insights on GLP-1 agonists, their clinical applications, and the latest research in hormone optimization. The conversation explores the mechanisms of action of GLP-1 compared to metformin, the target demographics for GLP-1 use, and the lesser-known benefits of these medications. Dr. Gillett also discusses emerging therapies such as amylin agonists and myostatin inhibitors, highlighting their potential in muscle growth and overall health. The episode concludes with a discussion on protein intake and its importance in muscle mass and bone health. In this conversation, Kyle Gillett discusses the implications of high protein diets on aging, the importance of various biomarkers in blood testing, and the role of creatine kinase in assessing training intensity. He delves into insulin sensitivity and its effects on muscle gain, emerging treatments like amylin agonists, and the benefits of methylene blue. The discussion also touches on nitric oxide levels and their impact on performance, providing a comprehensive overview of current trends in health and fitness.
Podcast Show Notes/Links:
Dr. Kyle Gillet’s IG: https://www.instagram.com/kylegillettmd/
Get Lucas’ New Supplement Here: https://www.inb4supps.com/
Disclaimer:
The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program.
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