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Challenges of Respiratory Viruses
- Respiratory viruses like SARS-CoV-2 enter through the nose and mouth, making infection prevention challenging.
- Vaccines given in the arm primarily induce antibodies in the blood, not at the site of entry.
Vaccine Goals
- The primary goal of vaccines should be to prevent severe disease, not necessarily infection.
- Antibody levels naturally decrease over time, while memory responses provide long-term protection against disease.
mRNA Vaccines
- mRNA vaccines use messenger RNA to create the SARS-CoV-2 spike protein within your cells.
- This method triggers a strong antibody and T-cell response, mimicking a live virus exposure.