The Jesse Chappus Show 680: Oxford Scientist Reveals What Ketones Really Do Inside Your Body | Dr. Latt Mansor
Nov 25, 2025
Dr. Latt Mansor is an Oxford-trained physiologist and metabolism expert focused on ketone biology. He explores the evolutionary role of ketones in fasting and their ability to fuel the brain. The discussion covers the impact of insulin resistance and metabolic flexibility, emphasizing the importance of switching between fuels for optimal performance. Latt shares insights on exogenous ketones, their use in training, and therapeutic potential for various diseases. Practical tips for enhancing ketone production and the benefits of combining ketones with caffeine and sleep are also highlighted.
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Ketones As An Ancient Alternate Fuel
- Ketones are ancient fuel molecules produced by the liver when glucose/glycogen are low.
- They cross the blood-brain barrier to supply the brain with ATP during fasting or low-carb states.
Ketones Bypass Insulin-Dependent Fuel Paths
- Ketones use MCT transporters and do not require insulin or GLUTs to enter cells.
- This makes ketones a critical auxiliary fuel when insulin resistance limits glucose uptake.
Metabolic Flexibility Is The Core Goal
- Metabolic flexibility means swapping fuels quickly (glucose vs fat/ketones) based on demand.
- Loss of flexibility forces inefficient metabolism and increases oxidative damage under stress.
