Behind The Knife: The Surgery Podcast Journal Review in Breast Surgery: Management of Hereditary Breast Cancer
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Apr 24, 2023 AI Snips
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Pathogenic Variant Versus VUS
- Pathogenic variants cause nonfunctional proteins and raise cancer risk, while VUSs are usually benign and get reclassified over time.
- Do not make clinical decisions based on a VUS; follow-up with genetic counseling for reclassification.
Start With Panel Testing And Counseling
- Use multi-gene panel testing for most patients and involve a genetic counselor when available to interpret results.
- Start with a focused breast cancer panel and leverage lower costs and company assistance for out-of-pocket expenses.
Who To Refer For Genetic Testing
- Refer patients for genetic testing guided by NCCN and society criteria, and consider testing all newly diagnosed breast cancer patients per the American Society for Breast Surgeons.
- Factor age, tumor biology, and family history when deciding testing urgency and involve counselors early.