Journal Review in Breast Surgery: Management of Hereditary Breast Cancer
Behind The Knife: The Surgery Podcast
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The Role of Pathogenic Gene Variants in Breast Cancer
There's a goal to develop therapies that are going to target the specific mutation that a cancer cell might have. The main one that's really come into clinical practice is in the setting of using PARP inhibitors for tumors that have brachia mutations, so BRC mutations. A person who does not have a germline variant in the brachia gene might spontaneously develop a cancer where the cancer cell has gotten a somatic mutation in thebrachia gene. Regardless of how it got that mutation, a cancer cell that has a brachia mutation can't repair double-stranded DNA breaks.
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