

459: How Psychedelics Are Transforming Mental Health by Healing Depression, Anxiety, PTSD, and More | Robin Carhart-Harris, PhD
Jan 29, 2025
Dr. Robin Carhart-Harris, a leading neuroscientist and founder of the Center for Psychedelic Research, dives into the transformative power of psychedelics on mental health. He discusses groundbreaking research highlighting their effectiveness in treating conditions like depression, anxiety, and PTSD. The conversation critiques traditional SSRIs, suggesting psychedelics foster emotional processing and neuroplasticity. Carhart-Harris underscores the need for further research and education to unlock the full potential of these therapies while addressing safety concerns.
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First Patient Transformation
- Robin Carhart-Harris describes the transformative experience of the first patient in his depression trial.
- The patient's demeanor shifted dramatically after psilocybin therapy, accompanied by unusual behaviors and visions.
Prevalence of Treatment-Resistant Depression
- Treatment-resistant depression affects at least 20% of those with depression.
- Depression is prevalent, affecting about 10% of the population, often alongside anxiety.
Chemical Imbalance Myth
- SSRIs increase serotonin levels, but depression isn't simply caused by low serotonin.
- The chemical imbalance theory is overly simplistic and used to market SSRIs.