Thomas DeLauer on The Mistakes You Should Avoid to Live Longer & Happier
Sep 18, 2023
auto_awesome
Thomas DeLauer, a nutrition and business performance coach with over 3.5 million YouTube subscribers, discusses longevity, key habits for a healthier life, hormetic stressors, calorie restriction, benefits of heat and cold therapies, and the role of FOX03 for longevity.
Genetics and lifestyle factors influence longevity by activating certain genes associated with health and anti-aging.
HDAC inhibition can promote longevity by affecting gene expression and unlocking genetic traits.
Sauna therapy has cardiovascular and brain health benefits and should be incorporated as part of a holistic approach to health and longevity.
Deep dives
The Importance of Genetics and Epigenetics for Longevity
Genetics and epigenetics play a crucial role in understanding longevity. Thomas Delauer discusses how our genes and epigenetic factors can influence the aging process and impact health span. He emphasizes the significance of understanding the balance between genetics and lifestyle factors, and how they can determine our ability to activate certain genes associated with longevity and health.
HDAC Inhibition and its Role in Longevity
HDAC inhibition, also known as histone deacetylase inhibition, is explored as one potential mechanism for promoting longevity. Thomas explains how HDAC inhibition can affect gene expression and unlock certain genetic traits that contribute to longevity. He discusses the importance of exercise, nutrition, and sleep in promoting HDAC inhibition and activating genes associated with anti-aging and health benefits.
The Benefits of Sauna Therapy for Performance and Health
Thomas shares his personal experience with sauna therapy and its impact on exercise performance and overall health. He highlights the cardiovascular benefits of sauna therapy and its ability to mimic the effects of exercise. Additionally, Thomas discusses the potential benefits of sauna therapy on brain health, including the potential for increasing intracranial pressure and promoting glymphatic function. He emphasizes the importance of incorporating sauna therapy as part of a well-rounded and holistic approach to health and longevity.
Importance of Prioritizing Big Things and Balance of Stressors
It is important to prioritize important aspects of life such as exercise and work before focusing on smaller actions like taking cold showers or supplements. While these smaller actions may have some benefits, they should not be the main focus. Balancing stressors in life is crucial, as overdoing it or stressing oneself in categories with minimal impact can be detrimental. By mildly stressing oneself with exercise, occasional caloric restriction, and rotating stressors, one can achieve better results without going to extremes.
Understanding Hormesis and the Role of FoxO3 in Longevity
Hormesis, the concept of applying stress in order to create resilience, is complex and delicate. One important factor in the stress response at a cellular level is the protein FoxO3. Activation of FoxO3 triggers a cascade of gene expression changes related to antioxidant production, combatting oxidative stress caused by various stressors like exercise. The presence of FoxO3 is crucial in promoting adaptation and combating cellular damage. While the timing and optimal implementation of specific stressors are still unclear, understanding the importance of stress response mechanisms like FoxO3 can contribute to overall longevity.
Can you live a longer, healthier life without sacrificing the things you enjoy doing?
This episode’s guest is Thomas DeLauer, a nutrition and business performance coach with over 3.5 million subscribers on YouTube. Thomas built his name around helping busy people live longer, healthier, and happier lives by making small diet and lifestyle changes.
In this episode, Thomas and I discuss:
Longevity and the keys to slowing down aging
The habits linked to a longer, healthier life
Hormetic stressors and why they’re important
What the science says about calorie restriction
The benefits of heat and cold therapies
The role of FOX03 for longevity
[00:00] Introduction [00:28] Thomas’ Understanding of Aging [02:27] Why Aging is Not Necessarily About Living Longer [05:07] What are HDACs? [09:25] How to Express and Activate Your Genes [12:35] Good Sleep For Health and Wellnes [14:20] The Science of Longevity Through a HDAC Lense [16:16] Sunlight and Other HDAC Inhibitors [20:43] Understanding Hormesis and Hormetic Stressors [25:26] How a Good Amount of Stress Affects Longevity [28:57] Thoughts on FOX03 [32:15] Is Calorie Restriction the Answer to Longevity? [34:20] Intermittent Vs Prolonged Vs Controlled Fasting [39:45] Thomas’ Thoughts on Meat and Plant-Based Diets [43:33] Heat Therapy: Benefits and Types [48:26] Mechanisms and Efficacy of Heat and Cold Therapies [51:52] Thomas’ Love For the Sauna [53:47] Is Sex Important For Longevity and Healthspan? [56:16] Parting Thoughts
Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at http://insidetracker.com/louisa
The Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode