ZOE Science & Nutrition

The science of weight loss – and why calories don’t count! | Prof. Giles Yeo

Jan 16, 2025

Giles Yeo, a Professor of Molecular Neuroendocrinology at the University of Cambridge and author of 'Gene Eating', challenges conventional weight loss myths. He reveals why calorie counting could hinder weight management and dives into the complexities of how genetics, brain signals, and gut health influence our weight. Yeo discusses the surprising effects of ultra-processed foods and offers insights on breaking free from yo-yo dieting by embracing a balanced, plant-rich diet for sustainable health.

01:03:41

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Episode guests

Giles Yeo

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Quick takeaways

Weight loss relies more on understanding the quality of food we consume rather than merely counting calories and restricting intake.

Genetics, brain signals, and gut health significantly influence our appetite and weight management, complicating the simplistic calorie counting approach.

Emphasizing a balanced diet rich in protein, fiber, and low sugar content can lead to more sustainable weight management outcomes.

Deep dives

Rethinking Weight Loss

Weight loss is often mistakenly viewed as a process of restriction, emphasizing calorie counting and exercise. Instead, a healthier perspective encourages saying 'yes' to whole foods, vegetables, and a varied diet. This shift allows individuals to explore the nutritional benefits of foods rather than solely focusing on limiting intake. The discussion highlights how understanding calories can lead to a more informed approach to eating without the pressure of strict diets.

Intro

3min

Understanding Calories: From Heat Measurement to Dietary Myths

3min

The Historical Foundations of Caloric Measurement

4min

The Evolution of Calorie Counting

22min

The Dessert Stomach Dilemma

4min

The Science of Appetite and Weight Loss

21min

Redefining Weight Loss: The Role of Satiety and Gut Health

5min

Think weight loss is all about eating less and moving more? Think again. In this episode, Prof. Giles Yeo reveals why calorie counting isn’t just inaccurate—it could actually make weight management harder. He explains why the popular “calories in, calories out” method doesn’t add up and explores how factors like genetics, brain signals, and gut health play a major role in shaping our weight.

Giles Yeo is a Professor of Molecular Neuroendocrinology at the University of Cambridge and Honorary President of the British Dietetic Association. His research focuses on the influence of genes on feeding behaviour and body weight. Giles is also the author of ‘Gene Eating’ and ‘Why Calories Don’t Count’.

Giles shares the surprising impact of ultra-processed foods on how we process calories and why losing weight often feels like a battle against our own biology. With decades of research in his back pocket, Giles shares science-backed advice to help you break free from yo-yo dieting, read calorie labels smarter, and embrace a more balanced, plant-rich diet for long-term health.

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Timecodes

01:17 The quickfire round on weight myths

02:05 The biggest weight loss myth revealed

03:07 What are calories, really?

04:08 Burning poop: a bizarre calorie experiment

08:05 The woman who invented calorie counting

11:41 How calories became a diet obsession

15:00 Why calorie counting doesn’t work

18:56 Why food quality matters more