The Peter Attia Drive #05 - Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer
02:43:06
Cancer Cell Vulnerability
- Cancer cells have a lot of mitochondria and produce excess free radicals under hyperbaric oxygen.
- This suggests a potential vulnerability to oxidative stress.
ROS and Cancer
- Cancer cells thrive at an elevated level of reactive oxygen species (ROS) but are vulnerable if ROS levels get too high.
- This presents a potential therapeutic strategy.
BHB and Cancer Growth
- D’Agostino observed that cancer cells didn't grow as rapidly in a medium with beta-hydroxybutyrate (BHB).
- This sparked his interest in ketones and cancer.
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Introduction
00:00 • 5min
I'm Doing Really Well. And I've Got a Question for You, Ken Ford. And So That Was the Night We Met
04:59 • 2min
Postdoctoral Fellowship in Neuroscience
06:42 • 2min
The Hyperbaric Atomic Force Microscope
08:29 • 2min
Using a Confoca Microscope to Image Cancer Cells
10:13 • 3min
Observation Two, Lots of Mitochondria in Cancer Cells
13:03 • 4min
Cancer Cells
16:36 • 3min
Cancer Cells Are Not Growing as Rapidly as They Should Be
19:21 • 6min
Is the Warburg Effect Presenta Present?
25:14 • 2min
The Warburg Effect on Cancer Cells
27:28 • 2min
Cancer Metabolism Conferences - Is There Another Reason Why?
29:12 • 2min
Cancer
30:57 • 2min
The Problem of Oxygen Toxicity Seizures
32:35 • 3min
Do You Know How Many Navy Divers Die From Seizures?
35:35 • 3min
The Adaptive Response to Oxydative Stress
38:24 • 3min
Hyperbaric Medicine
41:20 • 2min
Hyperbaric Oxen Therapy for Trematic Brain Injury
42:50 • 2min
Tbi
44:44 • 2min
Hyperbaric Auction Therapy
46:26 • 2min
Did George Khill Do the Exogenous Keytones?
48:09 • 2min
The Metabolic Effect of Beta Hydrox Buterate
50:04 • 2min
Is It a Triglyceride, or a Fatal Fatty Acid?
51:52 • 1min
Ylie Hant, You Theo Mice?
53:22 • 2min
How Much of Your Brain's Energy Comes From Glucose?
55:04 • 2min
What Are Key Tones and How Do They Change Your Metabolic Physiology?
56:39 • 2min
Ketogenic Diet - Key Tone Esters
59:02 • 3min
How to Make a Keytone Body?
01:02:20 • 3min
Is Aspertate Associated With Cancer Cells?
01:05:18 • 3min
Pritin, Medium Chain Triglyceride, and Metabolic Fats
01:08:41 • 2min
C a Oil
01:10:43 • 2min
Powdered Mc Ts
01:12:33 • 2min
Do M C Ts Cross the Blood Brain Barrier?
01:14:36 • 2min
The Anti Seizure Properties of Aketogenic Diet
01:16:50 • 2min
Can Exogenous Keytones Work for Seizures?
01:18:25 • 3min
The Keytones Are Driving Down Glucose Levels
01:21:09 • 4min
How Do We Measure Insolent Wasles?
01:25:10 • 2min
Is Your Urine Meter a Good One?
01:27:36 • 3min
Nemo 23: What Did You See That You Did Not Expect?
01:30:40 • 2min
Do You Think Temperature and Pressure Are the Differences?
01:33:03 • 3min
Then, Is It a Topagy Sky Rocket?
01:36:18 • 2min
Is That Vitali One Keytone?
01:38:13 • 2min
Is There a Triuster of Glyceral?
01:40:16 • 2min
The Keytone Salts Aren't Bad, but They're Good
01:41:48 • 2min
Is the Bata Hydroxy Buterate an Antimer?
01:43:53 • 2min
Do You Have an Anti Seizure Effect?
01:45:52 • 2min
Organic Chemistry
01:47:55 • 2min
The Best With Patrick - I Owe a Lot to Patrick
01:49:54 • 3min
Do Keytone Salts Have More Physiologic Benefits Than Keytones?
01:53:14 • 2min
Keytone Tolerance Test
01:54:59 • 2min
The Keyto Jenk Diet
01:56:52 • 2min
Is There an Upregulation of MCT in Athletes?
01:58:42 • 2min
G B M Versus Metostatic Bress Cancer?
02:01:07 • 5min
Is There a Reason Why You Shouldn't Consume Exogenous Ketones During the Fasting Period?
02:06:34 • 3min
Metabolism Is a Driver for Epigenetic Expression
02:09:23 • 3min
Reverse Tumor Hypoia Damages
02:12:42 • 4min
Do Anti Oxidents Really Work?
02:16:58 • 3min
Epilepsy and D Glucose
02:19:55 • 4min
Is Hyperbaric Oxygen Therapy a Good Therapy?
02:23:53 • 4min
Glucos Transporter Type One Deficiency - What's the Longest Fast You've Ever Doe?
02:28:10 • 4min
Keytone as an Alternative Energy Source
02:32:01 • 4min
The Metabolic Health Summit
02:35:49 • 4min
I Want to Thank You and Thank You for Sharing Your Knowledge
02:39:53 • 3min
Dom digs deep into the research and application of ketogenic diets, exogenous ketones, hyperbaric oxygen treatment, and treating cancer with a metabolic approach. Plus, we lost track of the number of n=Dom experiments mentioned in this episode.
We discuss:
- Dom’s early medical training in hyperbaric chambers [7:00];
- Effect of ketones on cancer cells [20:00];
- Ketones and oxygen toxicity seizures [32:00];
- HBOT & its many applications [40:00];
- Ketones, MCTs, and exogenous ketones [59:15];
- How ketones affect blood glucose [1:20:00];
- Ketone esters, salts, enantiomers vs. racemic BOHB [1:38:00];
- Dom’s ketone tolerance test [1:56:00];
- The metabolic management of cancer with a Press-Pulse approach [1:59:45]; and
- More.
Learn more at www.PeterAttiaMD.com