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ICU Ed and Todd-Cast
Old/New: HALT-IT and TXA in GI Bleed with cirrhosis
Apr 23, 2024
Explore the benefits of using tranexamic acid in managing upper gastrointestinal bleeding in cirrhosis patients based on the HALT-IT study findings. Delve into the use of tranexamic acid in critical care, analyzing the design, outcomes, and implications for patient groups. Discuss the enrollment triggers for drug use post-HALT-IT study and interpret relative risk increase in GI bleed with cirrhosis for accurate treatment decisions.
40:48
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Quick takeaways
- Transamic acid shows potential mortality benefit in cirrhosis GI bleeds.
- TXA use in cirrhosis GI bleeds may decrease re-bleeding instances.
Deep dives
Study on Transamic Acid for GI Bleeds in Cirrhosis Patients
A significant portion of patients with cirrhosis, experiencing GI bleeds, could benefit from transamic acid treatment based on the study. The trial highlighted a potential mortality benefit and reduced re-bleeding rates with this intervention in patients with child's Tercot-Pugh stage B and C cirrhosis. However, the trial, conducted in a single center, did not significantly impact blood product usage.
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Discover
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Listen to the best highlights from the podcasts you love and dive into the full episode