Featured Article Podcast: Intraoperative Methadone for Next-day Surgery
Sep 14, 2023
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Anesthesiology experts discuss the use of methadone in outpatient surgery, addressing misconceptions about the opioid crisis. They explore the various definitions and terminologies associated with outpatient surgeries. A dose escalation study on methadone for post-surgery pain management is discussed, highlighting the importance of managing acute pain. The significance of feasibility and pilot studies in testing treatments is emphasized. Methadone's potential in perioperative practice for pain management is explored.
A balanced and multimodal approach to pain management is recommended in outpatient surgery to prevent post-surgical complications and control severe pain.
Methadone, with its unique pharmacokinetics and analgesic properties, shows promise as a potential option for managing acute surgical pain, but larger phase three trials are needed to fully evaluate its benefits and risks.
Deep dives
The Opioid Crisis and Methadone Use in Outpatient Surgery
The podcast episode discusses the opioid crisis and the use of methadone in outpatient surgery. It emphasizes that the opioid crisis was not caused by anesthesiologists using opioids for surgery but by the overprescription of oral opioids for non-surgical patients. The episode challenges the idea of completely withholding opioids from patients during surgery and advocates for a balanced and multimodal approach to pain management. It highlights that pain after outpatient surgery can be just as severe as after inpatient surgery and the importance of adequately controlling it to prevent post-surgical complications and persistent pain. Additionally, it explores the unique pharmacokinetics of methadone, including its rapid onset and long duration of action, which make it a potential option for managing acute surgical pain. The podcast concludes by suggesting that further research, particularly larger scale phase three trials, is needed to fully evaluate the benefits and potential risks of methadone in different patient populations and surgical settings.
Feasibility and Pilot Study of Methadone in Next Day Discharge Outpatient Surgery
The episode focuses on a pilot study that aimed to determine the optimal dose of methadone for next day discharge outpatient surgery. It explains that the study successfully demonstrated the feasibility of using a single dose of methadone in this setting and collected high-quality data to identify the optimal dose. The study design was commended for considering both efficacy and feasibility outcomes. The podcast highlights that anesthesia with methadone resulted in lower in-hospital opioid use compared to short-duration opioids, and home pain and opioid use may also be lower with methadone. Notably, patients exhibited individual variability in opioid requirements following surgery. However, the small sample size and limited statistical power of the pilot study imply a need for larger phase three trials to further assess the analgesic effectiveness and safety profile of methadone in different patient populations and surgical contexts.
The Unique Characteristics and Underutilized Potential of Methadone
The podcast episode explores the unique characteristics of methadone that set it apart from other opioids. It explains that methadone is a mu opioid agonist with additional effects as an NMDA receptor antagonist, serotonin, and norepinephrine reuptake inhibitor. Its pharmacokinetics offer both rapid onset and long duration of action, making it a desirable option for perioperative analgesia. The episode shares the surprising finding from the study that even the highest doses of methadone did not eliminate the need for additional opioids in the recovery room, highlighting that outpatient surgery can still result in significant pain. It stresses the importance of individualizing pain management and discusses the potential role of methadone in tracking and managing the intensity of acute postoperative pain. The episode concludes by acknowledging the historical underutilization of methadone, attributing it to its association with opioid use disorder rather than its potential as an analgesic. It emphasizes the need for increased awareness and further studies to expand the understanding and acceptance of methadone in anesthesia practice.