Optimal Dose for Post-Surgery Pain Management with Methadone

This chapter discusses a dose escalation study on the use of methadone in post-surgery pain management. The study aimed to identify the optimal dose for patients undergoing specific types of surgery, and the data generated is valid and informative for future trials or for healthcare practitioners considering its use in their own practice. The chapter explores the unique characteristics of methadone and compares its onset of action to fentanyl, emphasizing the importance of managing acute post-operative pain to prevent chronic post-surgical pain.