The Marie Forleo Podcast 469 - Perimenopause Brain Fog & Fatigue? What Doctors Aren't Telling You
Dec 16, 2025
In this enlightening conversation, Mindy Pelz, a New York Times bestselling author and women's health expert, delves into the complexities of perimenopause. She shares her personal journey through hormone shifts, emphasizing the emotional toll and the importance of vulnerability in healing. Mindy creatively explains the concept of the 'Goo Phase' and introduces the Grandmother Hypothesis, highlighting the new ways women can redefine their purpose. With practical tools for restoring brain health and self-care, she empowers listeners to embrace this transformative stage of life.
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Breaking Point That Began Healing
- Mindy Pelz described a personal breakdown during perimenopause that included extreme stress intolerance, panic, and loss of function.
- She evacuated during fires, publicly announced "I'm not okay," and began healing by prioritizing herself.
Estrogen's Neurochemical 'Girl Gang'
- Estrogen withdrawal removes a 'girl gang' of neurochemicals like dopamine, serotonin, acetylcholine, GABA, oxytocin, and BDNF.
- That loss explains motivation, memory, calm, connection, and learning challenges many women face.
Speak Up About Suicidal Thoughts
- If you experience suicidal thoughts, tell a therapist or trusted person so others can monitor and support you.
- Seek help immediately; middle-age is statistically high-risk for suicide and warrants attention beyond hormones.