How Muscle Mass Impacts Sexual Function, Muscle Clock Genes, & The Power Of Isometrics - With Dr. Gabrielle Lyon

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Jan 7, 2026

Dr. Gabrielle Lyon, a board-certified physician and founder of the Muscle-Centric Medicine movement, shares fascinating insights on the crucial role of muscle mass in longevity and sexual health. She discusses a study showing a 73% increase in erectile dysfunction risk with low muscle mass. Exploring metabolic functions, strengthen your body through isometric exercises, and discover their injury-preventing properties. Tune in for practical tips on nutrition, sleep's importance in muscle growth, and how to build a resilient and functional body for life.

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INSIGHT

Muscle As A Metabolic Organ

Skeletal muscle functions as a metabolic organ that regulates carbs, fats, amino acids, and releases myokines.
Dr. Gabrielle Lyon links stronger muscle mass to better endothelial function and sexual health independent of hormones.

INSIGHT

Muscle Mass Linked To Sexual Function

Sarcopenia (low muscle mass/function) raises erectile dysfunction risk by about 73%.
Grip strength correlated with better erections independent of testosterone levels.

ADVICE

Use Isometrics For Pain Relief And Activation

Use isometric contractions to recruit muscle and relieve pain without stressing joints.
Apply isometrics to prime neuromuscular connection and protect tendons during recovery and training.

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Having an adequate amount of muscle mass on your frame can protect your longevity, improve your metabolism, and so much more. In fact, a new study showed a strong connection between muscle mass and sexual function. Today we’re going to deep dive this topic, including how you can apply science-backed strategies to get stronger for life.

Today’s guest, Dr. Gabrielle Lyon is a board-certified physician, New York Times bestselling author, and the founder of the Muscle-Centric Medicine movement. Her new book, The Forever Strong Playbook, shares the exact formula needed to build muscle for long-term health. Today, Dr. Lyon is back on The Model Health Show for an enlightening conversation on the role of muscle in sexual health and how to train for injury prevention and longevity.

This conversation highlights the importance of isometric exercises, including the top exercises to master to preserve functionality and mobility. You’re going to learn about muscle clock genes, the role sleep plays in muscle building, and so much more. Dr. Gabrielle Lyon is an absolute expert in this subject matter, and I hope you enjoy this conversation!

In this episode you’ll discover:

What percentage of men have erectile dysfunction. (2:48)
How muscle operates as a metabolic organ. (3:26)
The link between sarcopenia and erectile dysfunction. (5:03)
Why it’s critical to protect your tendon health. (9:03)
What an isometric exercise is and its role in injury prevention. (10:14)
Which nutrients are critical for collagen synthesis. (18:45)
What the Foundational 5 are and their purpose. (24:07)
The importance of being able to activate your posterior chain. (28:59)
Why muscle health and mental health are connected. (33:01)
What the muscle clock is. (43:08)
The definition of MPS. (47:43)
How your sleep impacts your ability to build muscle. (50:11)
Why thermal stress can improve your health. (1:00:43)

Items mentioned in this episode include:

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The Forever Strong Playbook by Dr. Gabrielle Lyon - Claim your preorder bonuses here!
Connect with Dr. Gabrielle Lyon Website / Newsletter / Podcast / Instagram

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