The Human Upgrade with Dave Asprey

The Secret Molecule for Endless Energy | Dr. Andrew Salzman : 1253

Feb 21, 2025

Dr. Andrew Salzman, a Harvard-trained physician and scientist renowned for creating the first PARP1 inhibitor, reveals the transformative power of NAD in enhancing energy and longevity. He discusses how NAD levels drop with age, leading to fatigue and disease risks. Discover the hidden enzyme CD38 that hampers your health, and learn actionable strategies to boost NAD naturally for better mitochondrial function. Salzman also challenges the conventional supplement industry, advocating for innovative approaches to aging and cellular health.

01:24:01

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Andrew Salzman

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Quick takeaways

NAD is essential for energy production and cellular repair, making its maintenance crucial for overall health and longevity.

Aging is viewed as a primary process affecting health, encouraging a focus on preventative strategies rather than isolated disease treatment.

Lifestyle factors like diet and exercise significantly influence NAD levels, highlighting the importance of healthy habits for optimal aging.

Deep dives

The Role of NAD in Energy and Health

NAD is a vital molecule that plays a crucial role in energy production within the body. It is essential for the creation of ATP, the primary energy currency in cells, which is necessary for brain function, muscle movement, and digestion. Additionally, NAD is involved in protecting the body against oxidative stress by aiding in the production of antioxidant defenses like glutathione. This multifaceted role underscores the importance of maintaining adequate NAD levels for overall health and vitality.

Intro

2min

From Patient Care to Scalable Solutions

4min

Unlocking Longevity: The Role of NAD

22min

Aging, Immunity, and Energy: The NAD Connection

11min

The Essential Role of NAD and Antioxidants in Cellular Health

6min

Enhancing Vascular Health Through NAD and Cialis

12min

The Importance of Consistent Energy Metabolism for Optimal Health

3min

Vitality and Aging: The NAD Connection

11min

The Connection Between NAD Levels and Effective Decision Making

3min

10.

Mitochondria, Glymphatics, and NAD: Unlocking Sleep's Power

8min

11.

Optimizing NAD Levels for Enhanced Longevity and Performance

4min

Could a single molecule be the difference between vibrant longevity and early decline?

Dr. Andrew Salzman—Harvard-trained physician, scientist, and creator of the first PARP1 inhibitor, Chief Medical Officer of Wonderfeel—joins Dave to reveal the real key to living longer, fighting disease, and maximizing your energy: NAD.

This master molecule fuels your mitochondria, DNA repair, and cellular resilience, but here’s the catch—it plummets as you age. That means more fatigue, brain fog, inflammation, and higher risks of disease. But what if you could stop the decline and even reverse it?

Dr. Salzman breaks down the game-changing science behind NAD, CD38, and cellular repair—and the fastest, most effective ways to optimize your levels for peak performance, health, and longevity.

Get ready to rethink everything you thought you knew about aging, pharmaceuticals vs. supplements, and the radical new approach to living better, longer.

What You’ll Learn:

• The #1 reason your NAD is disappearing—and how to fix it

• Why NAD is the missing link in energy, DNA repair, and disease prevention

• The hidden enzyme (CD38) that’s sabotaging your longevity

• How to supercharge mitochondria, optimize blood flow, and fight aging at the source

• Why the supplement industry has it wrong—and the best way to boost NAD naturally

• The shocking truth about the FDA, pharmaceuticals, and the future of anti-aging medicine

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Wonderfeel Instagram – https://www.instagram.com/getwonderfeel/

• Wonderfeel Supplement : https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast • 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

00:00 Trailer

01:07 Introduction and Episode Overview

02:29 Meet Dr. Andrew Salzman

02:36 From Physician to Researcher

03:39 Pharmaceuticals vs. Nutritionals

04:17 The Role of NAD in Longevity

06:32 Challenges in Longevity Research

12:58 Understanding NAD and PARP

14:34 NAD’s Impact on Health

23:19 Gut Health and Longevity

27:43 Innovations in NAD Supplementation

41:27 Customer Feedback and Product Effectiveness

42:41 Surprising Benefits of NAD for Sexual Health

44:47 NAD and Vascular Health

48:46 NAD’s Role in Aging and Longevity

54:03 NAD and Lifestyle Choices

01:03:02 NAD and Cognitive Function

01:06:18 NAD and Exercise

01:13:42 NAD and Sleep

01:21:54 Final Thoughts on NAD and Longevity

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The Human Upgrade with Dave Asprey

The Secret Molecule for Endless Energy | Dr. Andrew Salzman : 1253

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

The Role of NAD in Energy and Health

Understanding Aging as a Process

The Impact of Lifestyle on NAD Levels

NAD's Connection to Cancer Prevention

Innovations in NAD Supplementation

NAD's Role in Cognitive Function and Sleep

Remember Everything You Learn from Podcasts