

Ep. #1160: Sal Di Stefano on Enhancing Body Composition with Peptides
Jul 31, 2024
Sal Di Stefano, a seasoned fitness coach and co-host of the Mind Pump Podcast, dives into the fascinating world of peptides and their role in fitness. He discusses the surge in popularity of GLP-1s for weight loss, contrasting them with traditional calorie-controlled diets. Sal shares strategies to prevent muscle loss while using these compounds and warns about the risks of unregulated peptides. He also explores how these advancements may influence future workout habits and the supplement industry, providing valuable insights for fitness enthusiasts.
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GLP-1s & Peptides
- GLP-1 agonists are going mainstream, increasing peptide popularity.
- They cause significant weight loss, unlike any previous non-surgical intervention.
Culture Shifting Intervention
- GLP-1s could be a culture-defining medical intervention like birth control or antibiotics.
- Both positives and negatives will arise, requiring responsible use and mitigation strategies.
GLP-1s vs. Calorie Restriction
- GLP-1s cause more fat loss and less metabolic adaptation than calorie restriction alone.
- They also have a muscle-preserving effect, though some muscle loss still occurs.