LONGEVITY with Nathalie Niddam #400: Why Chasing Muscle for Longevity Might Backfire: The Real Keys to Aging Well With Joel Greene.
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Jan 2, 2026 Join Joel Greene, an author and longevity researcher known for his works on immunity and metabolism, as he challenges conventional wisdom about aging. He reveals that the pursuit of muscle may hinder mobility and longevity. Instead of rigid diet rules, he advocates for nutritional flexibility and highlights overlooked biomarkers like fasting insulin. Joel promotes practical movement routines, including daily hops for foot strength, and emphasizes spiritual well-being as a vital aspect of health. Discover why body fat percentage is the key longevity marker to track!
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Diet Modulates Immunity, Not Just Metabolism
- Diet effects on longevity must account for how nutrients directly alter immune-cell behavior, not just metabolic markers.
- Joel Greene shows saturated fat and sugar can change macrophage function and cancer-related immune switches.
Track Fasting Insulin And Acylcarnitines
- Measure fasting insulin and specific acylcarnitines to reveal metabolic and cardiovascular risk earlier than glucose alone.
- Test these overlooked biomarkers if you want a clearer picture of aging trajectory.
Chronic Ketosis May Depress ATP Over Time
- Long-term chronic ketosis can cause incomplete fatty-acid oxidation and acylcarnitine buildup that depress ATP production.
- That metabolic slowdown explains fatigue and reduced cellular energy over time.
