
Defiant Health Radio with Dr. William Davis Why it's crucial to keep triglycerides at 60 mg/dl or less
Jan 20, 2026
Triglycerides play a crucial role in heart health, yet they are often overlooked in favor of LDL cholesterol. Keeping triglyceride levels at 60 mg/dL or less can drastically reduce health risks. The podcast dives into how unhealthy carbohydrates contribute to triglyceride production in the liver. Natural dietary strategies, including cutting out grains and sugars, along with supplementing with omega-3s, can help achieve this goal. Listeners also discover the connection between gut health, endotoxins, and liver function.
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Triglycerides Trump LDL And Total Cholesterol
- Triglycerides are the most informative value on a standard cholesterol panel and matter more than total or LDL cholesterol.
- Dr. William Davis argues that a triglyceride level ≤60 mg/dL signals far lower heart disease risk and systemic metabolic problems.
Carbs Fuel Liver Triglyceride Production
- The liver converts carbohydrates and sugars into triglycerides via de novo lipogenesis, which are packaged as VLDL for blood transport.
- VLDL particles carry the triglyceride burden that initiates downstream atherogenic changes in LDL particles.
Small LDL Results From Triglyceride-Rich VLDL
- Triglyceride-rich VLDL interact with LDL particles to create small, dense LDL particles that are highly atherogenic.
- Small LDL particles circulate longer, penetrate artery walls easier, and provoke inflammation and oxidation more than large LDL.



