The Adversity Advantage with Doug Bopst How Feeling Lost, Empty & Depressed Is Silently Fueling Inflammation | Dr. Will Bulsiewicz
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Jan 15, 2026 
Dr. Will Bulsiewicz, a board-certified gastroenterologist and bestselling author, dives deep into the connection between gut health and chronic inflammation. He reveals how unresolved trauma and loneliness can impact our physical well-being, emphasizing that nutrition alone isn't the cure. Will shares his personal health journey and outlines four key dietary principles to reduce inflammation. He also highlights the importance of relationships and purpose in achieving holistic healing, making a compelling case for a comprehensive approach to wellness.
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Inflammation Is An Epidemic
- Chronic low-grade inflammation is an epidemic driving many mental and physical health issues.
- Will Bulsiewicz links this inflammation to widespread gut dysbiosis that creates a vicious cycle.
Gut Damage Drives Systemic Inflammation
- A damaged gut both creates and is created by systemic inflammation, producing a vicious cycle.
- Will presents this gut–inflammation link as causal, not merely associative.
Microbiome Is Deeply Personal
- The microbiome is highly personalized; even twins share only ~35% of microbes.
- Gut composition reflects the totality of your life, not just recent food choices.
