The Peter Attia Drive

#70 - David Sinclair, Ph.D.: How cellular reprogramming could slow our aging clock (and the latest research on NAD)

9 snips
Sep 9, 2019
David Sinclair, Ph.D., a Harvard genetics professor renowned for his aging research, shares groundbreaking insights into longevity. He discusses the Information Theory of Aging and how cellular reprogramming could potentially reverse aging. The conversation dives into the crucial role of sirtuin genes, methylation, and NAD's significance in cellular health. Sinclair also reveals the supplements he takes for longevity and explores cutting-edge research on human cellular reprogramming, offering a hopeful glimpse into the future of aging and healthspan.
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INSIGHT

Information Theory of Aging

  • David Sinclair connects Claude Shannon's Information Theory to aging.
  • Sinclair suggests a cellular "backup copy" exists, allowing for age reversal.
INSIGHT

DNA Methylation and Aging

  • DNA methylation, the addition of methyl groups to DNA, controls gene expression and cell identity.
  • Methylation patterns change with age, potentially causing cells to lose their identity.
INSIGHT

Methylation and Age Reversal

  • Restoring methylation patterns to a youthful state could reverse aging.
  • Cells can distinguish between original methylation and age-related noise.
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