We Study Billionaires - The Investor’s Podcast Network TECH007: Longevity Roadmap w/ Seb Bunney (Tech Podcast)
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Nov 5, 2025 
In this engaging discussion, Seb Bunney, an author and longevity expert, sheds light on the science of aging and the potential for extending human healthspan. He outlines how reclassifying aging as a disease could revitalize research funding. The conversation digs into Yamanaka factors that may reverse cellular aging and the role of sirtuins in longevity. Additionally, they explore how AI can transform regenerative medicine. Lastly, Seb contemplates the philosophical implications of living longer versus living better.
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Aging As Epigenetic Information Loss
- Aging may be a form of information loss in the epigenome rather than inevitable hardware decay.
- Epigenetic settings (which pages of DNA are read) drift with time and produce harmful noise in cells.
Reprogramming Cells With Yamanaka Factors
- Yamanaka factors are four genes that can reprogram specialized cells back toward an embryonic-like state.
- Pulsed activation in mice repaired tissues and reversed some age signs like vision loss.
Sirtuins And The NAD+ Connection
- Sirtuins are enzymes that maintain chromatin state and repair DNA, driven by NAD+ availability.
- Declining NAD+ with age reduces sirtuin activity, undermining gene silencing and repair.
