Sirtuins, NAD, mTOR and AMPK — Longevity Pathways

In this wide-ranging conversation, Preston and Seb unpack the biology of aging and the emerging science behind longevity. They take about epigenetics, sirtuins, Yamanaka factors, and how AI may accelerate regenerative medicine, offering a glimpse into the future of human health.

IN THIS EPISODE YOU’LL LEARN:

00:00:00 - Intro

00:05:04 - Why Aging Might Be a Disease—and What That Changes Scientifically
00:07:05 - What Epigenetics Is and How It Affects Cellular Aging
00:24:37 - How Yamanaka Factors Can Reset Cells and Potentially Reverse Aging
00:35:43 - The Role of Fasting, Cold, and Heat in Triggering Repair Pathways
00:30:22 - What NMN and Sirtuins Do in the Body and Their Role in Longevity
00:42:26 - How AI Could Simplify and Accelerate Breakthroughs in Aging Science
00:48:48 - The Philosophical Trade-Offs of Living Longer Versus Living Better

Disclaimer: Slight discrepancies in the timestamps may occur due to podcast platform differences.

BOOKS AND RESOURCES

• Related book: Lifespan: Why We Age―and Why We Don't Have To.
• Seb's website: Seb Bunney - The Qi of Self Sovereignty.
• Seb’s book: ⁠The Hidden Cost of Money⁠.
• X Account: Seb Bunney.
• Related⁠⁠⁠⁠⁠⁠⁠ books⁠⁠⁠⁠⁠⁠⁠ mentioned in the podcast.
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