Alfalfa Podcast 162. Can Science Cure Hangovers? (Ft. Zack Abbott of Zbiotics)
Oct 13, 2023
Founder of Zbiotics, Zack Abbott, discusses the science behind hangovers and the development of Zbiotics, a genetically engineered probiotic. Topics include the biology of hangovers, the benefits of drinking water while consuming alcohol, and the effects of alcohol on blood sugar and insulin. They also explore GLP1 drugs and their impact on food consumption, genetically engineered probiotics revolutionizing the industry, and the challenges of balancing science and business.
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Hangovers: Ethanol + Acetaldehyde, Not Dehydration
- Hangovers are primarily driven by ethanol effects and acetaldehyde, not simple dehydration.
- Acetaldehyde is formed in the gut by microbes and causes major next-day toxicity and inflammation.
The Gut Is A Major Source Of Acetaldehyde
- Gut microbes process some ingested alcohol into acetaldehyde but often lack the second enzyme to finish detoxifying it.
- This gut-produced acetaldehyde is absorbed into blood and contributes substantially to hangover symptoms.
Stop Earlier To Sleep Sober
- Stop drinking earlier to allow your liver to metabolize alcohol before sleep.
- Space drinks and stop your last drink 2–3 hours before bed to improve sleep and next-day function.