Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics cover image

Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics

Measuring Longevity: Latest Bio Age Research with Dr. Morgan Levine

Aug 1, 2022
Dr. Morgan Levine, renowned for her research on biological aging, talks about vetting bio age clocks, using standard labs to calculate bio age, challenges of cellular reprogramming, and racial disparities in biological aging.
01:09:13

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

  • Epigenetic clocks provide a measure of biological age, linked to age-related diseases and degeneration.
  • Lifestyle factors, such as exercise, diet, and sleep, can influence biological aging.

Deep dives

Epigenetic Clocks and Aging: Measuring Biological Age

Epigenetic clocks, which measure DNA methylation patterns across the genome, have emerged as a powerful tool in quantifying the aging process. These clocks provide a measure of biological age, which can differ from chronological age. Unlike chronological age, biological age is linked to the underlying changes in our bodies that drive age-related diseases and degeneration. Epigenetic changes in the DNA methylome, acting as an operating system for cells, contribute to the aging process. Various clocks have been developed and validated, allowing us to assess biological age and predict outcomes based on this measure. However, choosing a reliable clock requires consideration of factors such as construct validity and reliability, and it is advisable to use clocks that have been published and vetted in the scientific literature.

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