

Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics
Dr. Kara Fitzgerald
Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF
Copyright © 2023 by KF Education and Consulting, LLC
All Rights Reserved
Copyright © 2023 by KF Education and Consulting, LLC
All Rights Reserved
Episodes
Mentioned books

Sep 4, 2025 • 55min
Why Functional Medicine Is the Future of Longevity
Can functional medicine unlock the secrets to healthy aging? In this special preview of the Functional Medicine is Longevity Medicine™ Masterclass happening on September 17- September 19, 2025, Dr. Kara Fitzgerald sits down with three leading voices in medicine and research:
- Dr. Bob Rountree: functional medicine pioneer in integrative approaches to health
- Dr. Dale Bredesen: internationally recognized expert on Alzheimer’s prevention and reversal
- Dr. Charles Serhan: Harvard researcher on inflammation resolution and aging biology
Together, they explore how functional medicine reframes longevity by addressing root causes, supporting cognitive health, and resolving chronic inflammation.
Whether you’re a clinician, health professional, or simply passionate about living longer and healthier, this conversation offers a glimpse into the science and practical applications that are transforming longevity medicine.
WATCH NOW TO LEARN:
- Why functional medicine is central to extending healthspan
- The latest insights on Alzheimer’s prevention and brain health
- How inflammation resolution impacts aging and chronic disease
- What to expect in the full Functional Medicine is Longevity Medicine™ Masterclass
Learn more & register for the Masterclass here: www.functionalmedicineislongevitymedicine.com
THANKS TO OUR SPONSORS
DIAMOND
DUTCH: https://dutchtest.com/for-providers
Biotics Research: https://www.bioticsresearch.com/
GOLD
TimeLine Nutrition: https://tinyurl.com/bdzx2xms
Vibrant Wellness: https://www.vibrant-wellness.com/
EXCLUSIVE OFFERS FROM OUR SPONSORS
OneSkin: Get 15% off OneSkin with the code DRKARA at http://oneskin.co/DRKARA
Discover why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6

Aug 18, 2025 • 1h 22min
Why Centenarians Are Defying Science: Secrets to Living 100+
It was a pleasure to sit down with Dr. Nir Barzilai for a conversation that turned out to be both lively and thought-provoking. His decades of research on centenarians, biological age, and the hallmarks of aging have shaped how we think about longevity—and what’s possible when we start targeting aging itself, not just individual diseases.
We get into the science behind why some people live 20–30 years longer and healthier, and what it means to measure the biological age of individual organs. But we also hit a few sparks—especially when it comes to nutraceuticals and the role of metformin in prevention. I don’t agree with everything you’ll hear, and I followed up with Dr. Barzilai afterward to unpack some of the more provocative claims. We may just need a second round for this one... stay tuned.
Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Nir Barzilai M.D.
Director of the Einstein Institute for Aging Research
Professor of Medicine and Genetics
President of the Academy for Health & Lifespan Research
Website: https://einsteinmed.edu/faculty/484/nir-barzilai
Email: nir.barzilai@einsteinmed.edu
Dr. Nir Barzilai is a pioneer in aging science, known for his work on centenarians, the biology of aging, and the TAME trial. He is Director of the Institute for Aging Research at Albert Einstein College of Medicine and author of Age Later and has published over 330 papers.
THANKS TO OUR SPONSORS
DIAMOND
DUTCH: https://dutchtest.com/for-providers
Biotics Research: https://www.bioticsresearch.com/
GOLD
Vibrant Wellness: https://www.vibrant-wellness.com/
OneSkin: http://oneskin.co/DRKARA
EXCLUSIVE OFFERS FROM OUR SPONSORS
Find out why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6
OneSkin: Get 15% off OneSkin with the code DRKARA at oneskin.co/DRKARA
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You Practitioner Training Program: https://www.drkarafitzgerald.com/trainingyyi/
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Aug 5, 2025 • 53min
The Science-Backed Bitter Compound That Mimics GLP-1 (No Injections Needed!)
I’ve been watching the science behind Calocurb evolve over the last year, and I have to say—this is one of the most exciting clinical tools I’ve seen emerge in the metabolic space in quite some time. A hops-derived compound that stimulates endogenous GLP-1, CCK, and PYY—without a prescription or injection? That’s a big deal, especially for patients struggling with appetite regulation, weight plateaus, or the aftermath of GLP-1 discontinuation.
In this episode, I sit down with Sarah Kennedy, founder of New Zealand-based Calocurb, to talk about the years of government-funded research that led to this discovery, the remarkable clinical outcomes they’ve seen so far, and how I’ve personally used it in my practice with excellent results. If you’re looking for science-backed, natural strategies to support appetite control, fasting, or GLP-1 transitions—this one’s worth a listen. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Sarah Kennedy, Founder and CEO of Calocurb Ltd.
Email: sarah.kennedy@calocurb.com
LinkedIn: https://www.linkedin.com/in/sarah-kennedy-0a840b13/
Sarah Kennedy, BVSc, is a veterinarian and health industry leader with 20+ years in nutrition science and innovation. Now CEO of Calocurb, she brings a unique perspective on natural GLP-1 activation—bridging plant-based research, gut physiology, and clinical application.
THANKS TO OUR SPONSOR: Calocurb
EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS
Manage cravings and feel full faster with Calocurb, a 100% natural capsule that supports healthy weight management. Visit http://calocurb.com/drkara10 and use code DRKARA10 at checkout.
CONNECT with DrKF
Join Dr. Kara Fitzgerald and leading experts *LIVE on Sept 17–19, 2025* for a free virtual Masterclass on redefining healthcare & longevity through the lens of science-backed, systems-based approach. Register now: https://www.functionalmedicineislongevitymedicine.com/
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Jul 23, 2025 • 1h 17min
10 Year Anniversary: What I Learned After 200+ Conversations with the Best Minds in FxMed
In this very special episode, I have the privilege of turning the tables on Dr. Kara Fitzgerald as we celebrate 10 years of the New Frontiers podcast. I’ve been honored to walk alongside Kara on much of this journey—as a colleague, a collaborator, a mentee, and a friend—and it’s been incredible to witness the evolution of both her work and the field itself.
Together, we reflect on the stories, science, and people who have shaped this podcast—and the remarkable growth of epigenetics, personalized medicine, and functional medicine along the way. From early conversations around methylation and aging to hosting pioneers like Dr. Jeff Bland, Dr. Sidney Baker, and Dr. Charles Serhan, New Frontiers has become a living archive of how this field has moved forward.
As we talked about during the conversation: “Everybody is a piece of this ecosystem, and everybody has their role... It’s really cool to be part of that community.” This episode is a celebration of that collective journey—and a look at where we’re headed next. ~Romilly Hodges MS CNS
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
THANKS TO OUR SPONSORS
DIAMOND
Biotics Research: https://www.bioticsresearch.com/
DUTCH: https://dutchtest.com/for-providers
GOLD
Vibrant Wellness: https://www.vibrant-wellness.com/
TimeLine Nutrition: https://tinyurl.com/bdzx2xms
EXCLUSIVE OFFERS FROM OUR SPONSORS
OneSkin: Get 15% off OneSkin with the code DRKARA at http://oneskin.co/DRKARA
Find out why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You Group Program: https://tinyurl.com/4hvusavw
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Jul 8, 2025 • 47min
Dead Mitochondria Might Be Fueling Cardiovascular Aging — Here’s The Fix
This is a really exciting conversation with Dr. Davide D’Amico from Timeline, where we’re taking a closer look at Urolithin A and heart health. It should come as no surprise that this mitochondrial wonderkin of a nutrient is showing promise here—especially when you consider that 40% of the heart’s weight is mitochondria. That’s an extraordinary factoid, and one that really shifts how we think about aging in the cardiovascular system.
What’s particularly compelling in this new preclinical research is that restoring mitochondrial function may do more than just improve ejection fraction. It may also have ripple effects on other hallmarks of aging—like chronic inflammation, cellular stress signaling, and impaired autophagy. I’m thrilled Timeline is continuing to invest in both preclinical and clinical research on this front—and yes, I’m totally nerding out over what they’re up to. ~DrK
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Davide D'Amico, PhD: Director of Discovery and Translational Research at Timeline.
With over 15 years of experience in mitochondrial and aging biology, he contributed to developing Urolithin A as a science-backed, clinically validated nutritional product to enhance mitochondrial and muscle health.
THANKS TO OUR SPONSOR
Timeline: http://Timeline.com/kara10
Email: care@timeline.com
EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS
Mitopure is making impressive strides for cellular health and longevity. Get 10% off your first order at http://Timeline.com/kara10 with code Kara10.
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Jun 23, 2025 • 1h 11min
Why Human-Centered AI Is the Future of Medicine & Mental Wellness
In this conversation, Rana el Kaliouby, an Egyptian-American AI scientist and co-founder of Blue Tulip Ventures, explores the intersection of artificial intelligence and human emotions. She discusses how AI can enhance empathy in healthcare and family therapy through innovative technologies like Happy Pillar. The talk delves into ethical considerations of AI, emphasizing privacy and consent. Rana also underscores the importance of integrating AI in education, fostering understanding among young and old, to create a future where technology promotes genuine human connection.

Jun 9, 2025 • 1h
Legal Pitfalls That Could Destroy Your Practice & How to Avoid Them
In many ways, the legal side of functional medicine can feel like the Wild West—uncertain, unregulated, and full of risks. The reality is, we all want to have our practices legally buttoned up, but navigating the legal landscape can feel overwhelming—and expensive. What Scott Rattigan, creator of Functional Lawyer, shares in this episode is a real game-changer. He not only breaks down the complexities of the legal side of things but also offers real solutions for us—solutions that can make sure we're covered without the stress and uncertainty that often comes with it. Whether you're just starting out or growing your established practice, you're going to get actionable insights on how to avoid common legal pitfalls, protect your practice, and actually move forward with confidence. It’s a topic that’s been an unmet need for so long, and I'm so excited to bring this to you. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
EXCLUSIVE OFFER FOR NEW FRONTIERS LISTENERS
Download 5 Essential Legal Documents for Every Functional or Integrative Medicine Practice: https://www.functionallawyer.com/resource-downloads
GUEST DETAILS
Scott Rattigan, JD
Founder: Functional Lawyer: https://www.functionallawyer.com/kf
Co-founder: Origins Incubator - https://www.originsincubator.com/
The Junto Podcast Playlist: https://fxmedlaw.com/junto-youtube
LinkedIn: https://www.linkedin.com/in/scott-rattigan/
Email: info@functionallawyer.com
Phone: 941-229-0928
Scott Rattigan, JD, is the founder of Functional Lawyer, offering flat-rate legal solutions to help practitioners protect their licenses and grow their businesses. Inspired by helping his wife build her functional medicine practice, Scott provides high-quality legal support for health coaches, doctors, and more. He’s an attorney, internationally recognized speaker, host of The Junto with Scott Rattigan, bestselling author of The Practice of Telemedicine, and co-founder of the practice success software ReveliaDx.
THANKS TO OUR SPONSOR
Functional Lawyer: https://www.functionallawyer.com/kf
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

May 19, 2025 • 1h 11min
Why You’re Aging Faster Than You Think & How to Slow It
I’ve been looking forward to sharing this conversation with you because it’s one I’m truly passionate about. Today, we’re diving into the DunedinPACE epigenetic clock with one of its creators, the brilliant Dan Belsky. It’s a tool I use regularly with my patients, and one that’s transforming how we approach aging and interventions. While this show is a bit more technical than usual, the science is fascinating, and the real-world applications are incredibly valuable. This isn’t just about theory—it’s about practical insights that can change how we measure aging and track the effectiveness of the treatments we offer. Stick with us, and you’ll walk away with actionable knowledge that can make a difference in your practice. ~DrKF
Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources.
GUEST DETAILS
Daniel W Belsky, PhD
Website: www.belskylab.com
THANKS TO OUR SPONSORS
DIAMOND
DUTCH: https://dutchtest.com/for-providers
Biotics Research: https://www.bioticsresearch.com/
GOLD
TimeLine Nutrition: https://tinyurl.com/bdzx2xms
Vibrant Wellness: https://www.vibrant-wellness.com/
EXCLUSIVE OFFERS FROM OUR SPONSORS
OneSkin: Get 15% off OneSkin with the code DRKARA at https://www.oneskin.co/DRKARA
Why MitoQ’s mitochondria-targeting is a critical step for your healthspan and longevity strategy. https://tinyurl.com/4f8t7jt6
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You Group Program: https://tinyurl.com/4hvusavw
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

4 snips
May 5, 2025 • 1h 6min
What New Research Says About Cartilage Regeneration and Joint Longevity
Kiran Krishnan, a research microbiologist and co-founder of Microbiome Labs, dives into groundbreaking findings on cartilage regeneration. He discusses a natural combination of boswellia and celery seed extract that showed impressive results in osteoarthritis patients, boosting mobility and reducing pain. The clinical trials revealed significant markers of cartilage repair and a reduced need for traditional medications. Kiran emphasizes the vital connection between gut health and joint wellness, paving the way for innovative approaches to long-term joint health.

Apr 20, 2025 • 1h 6min
The Truth About Chronic Illness: How to Reset Your Nervous System & Slow Aging
We’ve all had patients struggling with chronic conditions like long COVID, fibromyalgia, Lyme disease, and chronic fatigue. Despite all the tools in our functional medicine toolkit, there’s still something missing. How can we truly help them? I’m excited to have Ashok Gupta back on the New Frontiers podcast to offer a new take on healing from chronic illness. He explains that many chronic diseases stem from a malfunction in the brain's threat detection system, where the body overreacts to perceived threats, triggering immune, nervous system, or mood responses, creating a vicious cycle. Ashok shares how retraining the brain and calming the nervous system can reset the body’s response to chronic stress and presents the growing body of research supporting the Gupta Program, including new subjective measurements like CRP showing its impact. What excites me most is the potential for this approach to help some of my toughest-to-treat patients. With more studies emerging, I’m increasingly hopeful this could be a game-changer. It’s a conversation you won’t want to miss! ~DrKF
Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources.
Complimentary Gupta Program Brain Retraining Subscription
If you are a practicing clinician with patients who suffer from an inflammatory condition, you are entitled to free access to one of the world's foremost neuroplasticity programs, and the only one with independent randomized controlled trial data.
To benefit, please visit https://www.guptaprogram.com/health
GUEST DETAILS
Ashok Gupta
Email: ashokguptaprogram@gmail.com
https://guptaprogram.com/
Ashok Gupta is an internationally recognized speaker, filmmaker, and health practitioner who specializes in supporting individuals with chronic illness. After overcoming ME (Chronic Fatigue Syndrome) through his own neuroplasticity research, Ashok developed the Gupta Program in 2007 to help others recover. He has published several medical papers and continues to research chronic conditions, with recent studies demonstrating the effectiveness of the Gupta Program. Ashok is dedicated to advancing holistic approaches to healing and improving outcomes for those facing chronic illness.
THANKS TO OUR SPONSORS
DIAMOND
DUTCH: https://dutchtest.com/for-providers
Biotics Research: https://www.bioticsresearch.com/
GOLD
TimeLine Nutrition: https://tinyurl.com/bdzx2xms
Vibrant Wellness: https://www.vibrant-wellness.com/
EXCLUSIVE OFFERS FROM OUR SPONSORS
OneSkin: Get 15% off OneSkin with the code DRKARA at oneskin.co/DRKARA
MiToQ: Target mitochondria for better health and longevity with MitoQ’s advanced supplements at https://tinyurl.com/4f8t7jt6
CONNECT with DrKF
Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz
YouTube: https://tinyurl.com/hjpc8daz
Instagram: https://www.instagram.com/drkarafitzgerald/
Facebook: https://www.facebook.com/DrKaraFitzgerald/
DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw