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Regular exercise has been found to have several positive effects on cancer prevention. According to leading cancer researcher Catherine Schmitz, exercise reduces the likelihood of developing multiple common cancers, including breast, bladder, colon, endometrial, esophageal, renal, and gastric cancers. This reduction in risk ranges from 10% to 20%. The protective effects of exercise are independent of obesity and sedentary behavior. Exercise has a profound impact on insulin levels and inflammation, influencing the quality of fat and muscle tissues, which are key factors in cancer development. Moreover, exercise increases insulin sensitivity, leading to a lower likelihood of cancer incidence. While genetic predisposition plays a role in cancer development, exercise has been shown to reduce mortality and improve outcomes in individuals who have been sedentary and have had cancer. Furthermore, exercise is beneficial for pre-habilitation, improving function and outcomes prior to cancer treatment, and reducing hospitalization and pain following surgery. Lifelong exercise is ideal, but individuals who start exercising after a sedentary lifestyle can still benefit from significant reductions in cancer-related mortality. There is a need for healthcare providers to prioritize exercise as part of cancer prevention and treatment strategies, especially given its wide range of positive effects.