Immune

Immune 64: A tangled web of wires

Jan 24, 2023

Immunology experts Cindy, Steph, Brianne, and Vincent review diverse papers on immune system wiring, streptococcus vaccines, SARS-CoV-2 mRNA vaccination's IgG4 switch, B cell insights, unique antibodies against streptococcus, impact of SARS-CoV-2 exposure on immunity, and diverse immune responses from continuous germinal center invasion.

01:50:11

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Quick takeaways

Identification of new cell-cell interactions in the human immune system through advanced technologies

Shift towards non-inflammatory IgG4 antibodies after multiple mRNA COVID-19 vaccinations raises questions on vaccine efficacy

Certain antibodies can bind two different epitopes on the M1 protein, promoting phagocytosis and stabilizing the FC region

Deep dives

Molecular Insight into Immune System Interactions

The study delves into the complex interactions of the immune system focusing on the physical wiring diagram of the human immune system. By utilizing advanced technologies, researchers identified new cell-cell interactions and increased known interactions by 20%. Key findings include a platform, CIVEXIS, that screens 630 proteins, revealing novel ligands for immune receptors and the specificity of immune receptor interactions.

Introduction

2min

Decoding intricate immune cell interactions through CIVEXIS analysis

13min

Journey through Childhood Infections and Vaccine Development

18min

Immunological Response to mRNA Vaccination

11min

Exploring the Role of B Cells in Inflammatory Bowel Disease

10min

Innovative Method for Single-Cell Transcriptomics and Spatial Mapping in Tissue Sections

1min

B Cell Depletion and Tissue Repair in Mice

4min

Specialized Antibodies and Vaccine Development

18min

Enhanced Immune Response and Vaccination Strategies

11min

10.

Challenges in Studying Neutrophils and Unveiling Silent Flagellins' Interaction with TLR5

6min

11.

Diversifying the Immune Response Through Germinal Centers

11min

12.

Reflections on Bias, Bacteria, and Fundamentals in Immunology

2min

13.

Winter Weather, Lab Setup, and Research Reminiscence

2min

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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Links for this episode

MicrobeTV Discord Server
Tangled web of wires (Nature)
Path to group A Streptococcus vaccines (Clin Inf Dis)
Immune end-types predictive of vaccine responses (Nat Immunol)
IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol)
Very bad B cells (Immunity)
Two epitope Streptococcus monoclonal (EMBO Mol Med)
Predictor of vaccine-induced antibody responses (Nat Immunol)
Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med)
Neutrophilic inflammation and RSV infection (Science)
Commensals avoiding recognition (Sci Immunol)
Continuous germinal center invasion and immune response diversity (Cell)
Time stamps by Jolene. Thanks!

Music by Steve Neal Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

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Immune

Immune 64: A tangled web of wires

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

Molecular Insight into Immune System Interactions

Vaccine Response and Antibody Evolution

B Cell Influence on Tissue Repair

Specialized Antibodies Binding Two Epitopes on M Protein Enhance Phagocytosis

Transcriptional Atlas of Human Immune Response to Various Vaccines Reveals Patterns

Neutrophil-Driven Symptomatic Response to Flagellins from Human Gut Commensals

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highlights

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Immune

Immune 64: A tangled web of wires

Episode guests

Podcast summary created with Snipd AI

Quick takeaways

Deep dives

Molecular Insight into Immune System Interactions

Vaccine Response and Antibody Evolution

B Cell Influence on Tissue Repair

Specialized Antibodies Binding Two Epitopes on M Protein Enhance Phagocytosis

Transcriptional Atlas of Human Immune Response to Various Vaccines Reveals Patterns

Neutrophil-Driven Symptomatic Response to Flagellins from Human Gut Commensals

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Save anymoment

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