Immune 64: A tangled web of wires
Immune
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Diversifying the Immune Response Through Germinal Centers
The chapter explores a study on how germinal centers recruit and diversify naive B cells. It discusses the entry of both high and low affinity B cells, their contributions to antibody diversity, and clonal expansion. The conversation delves into the impact of invader B cells on peptide sequence divergence, the role of high affinity antibodies, and the challenges in developing effective vaccines amidst competition between different affinity antibodies.
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