The Dr. Hyman Show Fix Your Brain by Fixing Your Body: Metabolic Psychiatry Explained by Dr. Shebani Sethi
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Sep 24, 2025 
Dr. Shebani Sethi, a Clinical Associate Professor at Stanford and pioneer in Metabolic Psychiatry, dives into the connection between metabolism and mental health. She reveals how metabolic dysfunction can lead to mood and focus issues. Learn about metabolic red flags, essential tests for mental health, and everyday steps to enhance brain resilience. Dr. Sethi highlights the importance of nutrition and inflammation management while emphasizing that addressing root causes over symptoms could change psychiatric treatment forever.
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Metabolic Psychiatry Reframes Mental Illness
- Metabolic psychiatry studies how systemic and central metabolic dysfunctions drive psychiatric disease.
- Fixing body metabolism (inflammation, mitochondria, insulin) can prevent and treat mental illness.
Insulin Resistance Raises Depression Risk
- Insulin resistance is common and dramatically raises depression risk even without prior psychiatric history.
- One in three Americans have insulin resistance and it doubles depression risk.
Brain Glucose Hypometabolism Is Central
- Cerebral glucose hypometabolism appears in schizophrenia, bipolar and neurodegeneration before diagnosis.
- Brain insulin signaling and glucose handling influence plasticity, growth and psychiatric symptoms.
