Boundless Life

Rapamycin For Age Reversal: Everything You Need To Know (& Why Most People Are *Wrong* About True Gut Health!)

12 snips
Sep 14, 2023
In this engaging talk, Ross Pelton, a renowned pharmacist, nutritionist, and author specializing in anti-aging, explores the revolutionary compound rapamycin. He discusses its journey from antifungal roots to its potential in longevity and muscle preservation. Ross dives into the interplay between mTOR and autophagy, clarifying misconceptions around rapamycin's effects on fitness. The conversation also touches on gut health, the importance of diet, and practical tips for healthy aging, making it a treasure trove of insights for anyone interested in longevity.
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ANECDOTE

Rapamycin Discovery

  • Rapamycin, an antifungal and immune suppressant, was discovered in the 1960s on Easter Island.
  • It's produced by bacteria in the soil and named after Rapa Nui, the indigenous name for the island.
INSIGHT

Weekly Rapamycin

  • Joan Mannick's research revealed the benefits of weekly rapamycin doses for boosting the immune system in elderly people.
  • This challenged its image as an immunosuppressant, paving the way for its recognition as a life-extension drug.
INSIGHT

mTOR and Autophagy Imbalance

  • mTOR senses nutrient availability and signals cell growth, while autophagy activates when nutrients are scarce, cleaning and rebuilding cells.
  • Modern overeating keeps mTOR active, suppressing crucial autophagy.
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