In our first programme of the year, we gathered a group of scientific experts directly involved in analysing the structure and impact of the SARS- Cov-2 coronavirus. There were concerns over the emergence of two new variants, Alpha and Beta, especially whether these variants might spread more quickly, or outmanoeuvre the suite of new vaccines that were about to be rolled out. Now the same questions are being asked about the Omicron variant’s ability to spread and overcome our defences. We’ve invited the same scientists back to give us their assessment of our journey with Covid-19 over the past year, and discuss their findings on Omicron.The programme features: Ravi Gupta, Professor of Clinical Microbiology at the University of Cambridge Tulio de Oliveira, Professor of Bioinformatics, Stellenbosch University, South Africa Dr Allie Greaney from the Medical Scientist Training Program at the University of Washington School of Medicine Professor Jeremy Luban from the Broad Institute of MIT and HarvardPresenter: Roland Pease Producer: Julian SiddleImage: Local residents queue to receive a dose of the Covid-19 vaccine in Parkhurst, Johannesburg (Credit: Luca Sola/AFP via Getty Images)

Studies from South Africa and the UK suggest Omicron may be a mild infection for the majority of people. Hospital admissions are down when compared with other variants. However, the virus is replicating at a much faster rate than earlier variants and is able to overcome vaccines to some extent. Cases studies so far have mainly been in young people. There is concern over what will now happen as Omicron spreads across Europe and the US where there are older unvaccinated populations. Anne von Gottberg from South Africa’s National Institute for Communicable Diseases tells us what early results from studies there show and discusses the implications. Typhoon Rai in the Philippines led to the loss of many lives and even destroyed buildings designed to resist such extreme weather events. Could more have been done either to predict the ferocity of the typhoon or to prepare for its impact? Liz Stephens, Associate Professor in Climate Risks and Resilience from the University of Reading discusses these issues.Beavers are making a comeback – in the Arctic. Their activity in engineering the landscape, building dams, and changing water courses is so widespread it can be picked out by satellites. However, this is not entirely welcome says Helen Wheeler Senior Lecturer in Zoology at Anglia Ruskin University. who has been working with local people concerned about the beavers impact on their livelihoods.And the James Webb telescope is finally launching. Heidi Hammel, who has been involved in the project for over 20 years tells us what it’s all about. (Image: Getty Images)Presenter: Roland Pease Producer: Julian Siddle

A study from Hong Kong university shows Omicron replicates 70 times faster than two earlier variants of the SARS-Cov-2 virus. Virologist Malik Peiris, explains how tests using cells from the wind pipe showed the dramatic difference, which supports observations of increased transmission. In contrast Omicron replicated less well than other variants on cells from dep in thre lung – offering some possibility that it may produce mild infections.Tornados in the US do not normally occur in December. The one which swept across Kentucky and 3 other states was fuelled by weather patterns likely to have been influenced by long term climate change says Geographer James Elsner of Florida State University.The Parker Solar probe continues its mission of flying closer and closer to the sun. Results just published show what the data the probe picked up when it dipped into the surrounding plasma. NASA’s Nicky Fox is our guide.And how many legs does a millipede have? Until now not as many as you might think. Entomologist Paul Marek of Virginia Tech reveals the Australian specimen with more legs than ever seen before.(Image: Omicron variant (B.1.1.529): Immunofluorescence staining of uninfected and infected Vero E6 cells. Credit: Microbiology HKU/BSIP/Universal Images Group via Getty Images)Presenter: Roland Pease Producer: Julian Siddle

Which came first the volcano or the rain? Volcanic eruptions are known to influence global climate systems, even leading to the cooling of the planet. However local weather conditions can also influence the timing and ferocity of volcanic eruptions. As volcanologist Jenni Barclay explains rainwater can contribute to volcanic instability and even increase the explosiveness of eruptions. Syria has been experiencing civil war for more than 10 years. Many people have left including many of the country's scientists. We speak with 3 exiled Syrian scientists Shaher Abdullateef, Abdulkader Rashwani, and Abdul Hafez about their current work, which involves working with other academics and students in Syria sometimes remotely and sometimes directly. New findings from Chile reveal an unknown Tsunami emanating from an earthquake there in the 1700s. Historical records mention other ones, but not this one. Geoscientist Emma Hocking found the evidence in layers of sand. And we discuss the development of tiny robot-like structures made from frog cells, they can move and build other copies of themselves. Sam Kreigman and Michael Levin explain how. (Image: Eruption of Semeru. Credit: Getty Images)Presenter: Roland Pease Producer: Julian Siddle

South Africa announced their discovery of the Omicron variant to the world as quickly as they could. The response from many nations was panic and the closure of transport links with southern Africa. Tulio de Oliveira who made the initial announcement and leads South Africa’s Centre for Epidemic Response and Innovation tells us this is now having a negative effect on the country, with cases rising but vital supplies needed to tackle the virus not arriving thanks to the blockade. Omicron contains many more mutations than previous variants. However scientists have produced models in the past which can help us understand what these mutations do. Rockefeller University virologist Theodora Hatziioannou produced one very similar to Omicron and she tells us why the similarities are cause for concern. Science sleuth Elisabeth Bik and Mohammad Razai, professor of Primary Care in St George’s University in London have just been awarded the John Maddox Prize for their campaigning investigations in science. Elisabeth is particularly concerned with mistakes, deliberate or accidental in scientific publications, and Mohammad structural racism in approaches to healthcare. Laura Figueroa from University of Massachusetts in Amhert in the US, has been investigating bees’ digestive systems. Though these are not conventional honey bees, they are Costa Rican vulture bees. They feed on rotting meat, but still produce honey.Presenter: Roland Pease Producer: Julian Siddle(Photo: Vaccination centre in South Africa administering Covid-19 vaccine after news of Omicron variant. Credit: Xabiso Mkhabela/Anadolu Agency/Getty Images)

DART is a space mission designed to hit a distant asteroid and knock it slightly out of orbit. It’s a test mission, a pilot project for a way of potentially protecting the earth from a stray asteroid. We hear from mission coordinators Nancy Chabot and Andy Rivkin, both from the Applied Physics Labs, APL, of Johns Hopkins University.A new kind of Covid-19 vaccine has successfully undergone preliminary tests. Tuebingen University’s Juliane Walz tells us about how it hopes to stimulate a longer lasting protective effect against the virus than current vaccines. And Haley Randolph of Chicago University sheds light on how our ancient ancestors’ exposure to viruses influences our susceptibility today. Historian Robert Schulmann gives us an insight into the significance of research notes by Albert Einstein and Michele Besso. Sold at auction in France the notes give an insight into the collaboration between the two scientists which led to much of what we now understand about the fundamentals of physics.Image: NASA's DART Spacecraft Launches in World's First Planetary Defense Test Mission Credit: NASA/Bill IngallsPresenter: Roland Pease Producer: Julian Siddle

The political message from the COP meeting was a fudge over coal, but what does the science say? Surprisingly India seems to be on track to switch away from coal to renewables. We explore the apparent contradiction with Lauri Myllyvirta of the thinktank Centre for Research on Energy and Clean Air. Also a synchrotron for Africa, how such a project would give a boost to scientific development across the continent, with Marielle Agbahoungbata from the X-tech Lab in Seme City in Benin. Moriba Jah, who leads the Computational Astronautical Sciences and Technologies Group, at the University of Texas, in Austin, tells us what he saw when an exploding Russian satellite sent a shower of debris into the path of the International Space Station. And the animals that carry SARS-Cov-2, an analysis from Barbara Han of the Cary Institute of Ecosystem Studies in New York shows there are many more than previously thought.Image: A coal-fired power station in Nanjing in east China Credit: Feature China/Barcroft Media via Getty ImagesPresenter: Roland Pease Producer: Julian Siddle

Up to 8 percent of deer sampled in studies in the US were found to be infected with the SARS-Cov-2 Virus. Suresh Kuchipudi from the Department of Veterinary and Biomedical Sciences at Penn State University in the US says what they are seeing is a mixture of human to deer and deer to deer transmission of the virus. There is concern that its presence in animal reservoirs could lead to a new form of the virus emerging. Tropical forests and spread of zoonotic diseases And as the Cop26 meeting in Glasgow draws to a close we ask how global policy on climate will impact the spread of zoonotic disease. Spill over of possible pandemic pathogens from animals to humans occurs with the destruction of tropical forests in particular and can expose people to previously unknown zoonotic diseases such as Covid 19.Aaron Bernstein from the Coalition to Prevent Pandemics at the Source says healthcare initiatives designed to reduce the potential spread of such diseases need to be designed to work in tandem with conservation and climate change impact reduction initiatives, essentially tackling both problems simultaneously.LED lighting Researchers in South Africa are looking into ways of making LED lighting both cheaper and more efficient. This should help reduce energy consumption, a prerequisite for effective policy on climate change.In addition, as Professor Odireleng Martin Ntwaeaborwa tells us, the technology now has many applications in places where access to electricity is limited, including South Africa which currently has regular power outages. Personalised medicine And personalised medicine based on our genes took a further step forward this week. Richard Scott, Chief Medical Officer for Genomics England discusses new findings which reveal the genetic basis for a range or rare diseases. Image: Bambi, lobbycard, 1942 Photo by LMPC via Getty ImagesPresenter: Roland Pease Producer: Julian Siddle

Scientists in Switzerland have developed a system which uses solar energy to extract gases such as hydrogen and carbon dioxide from the air and turns them into fuels for transport. So far they have only made small quantities in experimental reactors, however they say with the right investment their alternatives to fossil fuels could be scaled up to provide a climate friendly way to power transport, particularly aviation and shipping. We speak to Aldo Steinfeld and Tony Patt from ETH Zurich and Johan Lilliestam from the University of Potsdam.And what will rises in global temperature mean where you live? An interactive model developed by Bristol University’s Seb Steinig shows how an average global rise of say 1.5C affects different regions, with some potentially seeing much higher temperatures than others. Dan Lunt – one of the contributing authors to this year’s IPCC report discusses the implications.We also look at racism in science, with problems caused by decisions on the naming of ancient bones more than 200 years ago. As more is known about human evolution, the way we classify the past seems to make less sense says Mirjana Roksandic.And the issue of colonialism looms large in the international response to conservation. Its legacy has been discussed at COP26 and as Lauren Rudd, author of a new study on racism in conservation tells us, this hangover from colonial times is limiting the effectiveness of current conservation initiatives.Image: President Biden and his wife travelling to the G20 summit in Rome and COP26 in Glasgow. Photo by BRENDAN SMIALOWSKI/AFP via Getty Images.Presenter: Roland Pease Producer: Julian Siddle

Just a few days before COP26 opens in Glasgow, the World Meteorological Organisation reported record greenhouse gas levels, despite a fall in CO2 due to pandemic restrictions. The UN Environment Programme’s Emissions Gap Report also revealed that current country pledges will only take 7.5% off predicted greenhouse gas emissions by 2030, well below the 55% needed to limit global warming to 1.5C. Worse still, many large emission producers are not on track to meet their countries’ pledges. Rachel Warren, Tyndall Centre for Climate Change Research, tells us the 1.5C limit is still achievable if we work in tandem with nature. Research by Sara Mikaloff-Fletcher, National Institute of Water and Atmospheric Research (NIWA), illustrates this. Her contribution to the WMO Greenhouse Bulletin revealed that New Zealand’s indigenous forests play a bigger role in absorbing carbon from the atmosphere than previously thought. Also on the programme, Abinash Mohanty, Council on Energy, Environment and Water, has been mapping climate vulnerability in India and explains why communities should be at the forefront of climate adaptation and mitigation strategies. And particle physicist Claire Malone shares her insights on how we can help women thrive in science, technology, engineering and mathematics (STEM) fields.Picture: Aerial shot at the edge of Lake Carezza showing storm damaged forest, Dolomites, Italy, Credit: Abstract Aerial Art/Getty ImagesPresenter: Roland Pease Producer: Samara Linton