Hong Kong had been very successful at preventing the spread of Covid-19. Testing and isolation measures were very effective. However, vaccine uptake was low amongst elderly people and that says virologist Malik Peiris has now left them vulnerable to the highly infectious Omicron variant. The bombing of a scientific institute in the Ukrainian city of Kharkiv has echoes of the Stalinist purges says physicist and historical Mikhail Shifman. He tells us how the institute developed as a leading centre for physics in the 1930s, but scientists there fled or were murdered after being targeted by Stalin’s regime.Economic sanctions and other measures designed to isolate Russia are likely to have an impact on Russian participation in international scientific collaborations. Nikolay Voronin from the BBC’s Russian Service gives us his assessment of the immediate impact and, if the conflict continues long term, the potential for Russian science to retreat the kind of isolation last seen during the cold war.Presenter: Roland Pease Producer: Julian Siddle(Photo: Patients wearing face masks rest at a makeshift treatment area outside a hospital, following a Covid-19 outbreak in Hong Kong, 2 March, 2022. Credit: Tyrone Siu/Reuters)

Wuhan's Huanan Seafood Market is associated with many of the first cases or Covid- 19, but data on precisely how and from where the virus might have first spread has been difficult to find. However a re-examination of the earliest samples collected from the market seem to pinpoint where the virus first showed itself. Sydney University virologist Eddie Holmes says this evidence will be crucial in determining which animals may have initially passed the virus to humans. Humans are known to have passed the Sars-Cov-2 virus to other animals, including cats, mink and deer. Canadian researchers have recorded the first incident of a modified form of the virus passing back from deer to humans. Virologist Samira Mubareka from the University of Toronto explains the implications. Chernobyl, the site of the worlds worst nuclear accident is back in the news as the Russian invasion of Ukraine led to a stirring up of nuclear material when troops entered the site. Ukraine has a number of nuclear reactors, Claire Corkhill, professor of nuclear materials at Sheffield University explains the potential risks from the current conflict and safeguards in place.And we hear from Svitlana Krakovska Ukraine's representative on the Intergovernmental panel on Climate Change, on her thoughts on the prospects for climate action and scientific progress in Ukraine. Image: Disinfection Work At Wuhan Huanan Wholesale Seafood Market, China 4 March 2020. Credit: Zhang Chang / China News Service via Getty Images.Presenter: Roland Pease Producer: Julian Siddle

A scheme in the US designed to prevent industrial espionage and the theft of intellectual property, is to be refocused after it was accused of unfairly targeting Chinese American scientists. We speak to Gang Chen, a professor from MIT who was falsely accused of financial crimes, and Holden Thorp Editor in Chief of the Journal Science who tells us why the ‘China Initiative’ is at odds with the reality of international scientific collaboration. And a huge study of farmed animals in China, from raccoon dogs to porcupines and Asian badgers, reveals that they carry a wide range of pathogens, including forms of avian flu and coronaviruses. Virologist Eddie Holmes from the University of Sydney, who was involved in the analysis, says these viruses may have the potential to jump species and infect humans – possibly leading to another pandemic.(Image: Students. Credit: Getty Images)Presenter: Roland Pease Producer: Julian Siddle

Messenger RNA-based vaccines have been used successfully to kick start the antibody production needed to fight Covid-19. Now the technology has been successfully used to encourage the growth of new bones to heal severe fractures. The technique seems to work far better than the current alternatives says Maastricht University’s Elizabeth Rosado Balmayor.Ivory smuggling continues to be a lucrative business for international criminal gangs, however, DNA techniques to trace where ivory seized by law enforcement authorities originates are now so accurate that individual animals can be pinpointed to within a few hundred miles. This says Samuel Wasser at the University of Washington, can be used as evidence against those ivory trafficking gangs.And we look at development in attempts to detect and weigh neutrinos, elusive subatomic particles essential to our understanding of the makeup of the universe. Physicist Diana Parno from Carnegie Mellon University takes us through the latest findings.Philologists have borrowed a statistical method from ecology to try and work out how much medieval romantic literature has been lost. The results seem to depend on which languages were involved, and like ecological systems, whether they were shared in isolated communities says Oxford University’s Katarzyna Kapitan(Photo: A doctor points to a x-ray of a woman's hand broken small metacarpal bone. Credit: Miguel Medina/AFP/Getty Images)Presenter: Roland Pease Producer: Julian Siddle

The Wuhan Institute of Virology has been at the centre of a controversy surrounding the origins of the virus which caused the Covid-19 pandemic. The work of the lab's previously obscure division looking at bat coronaviruses has been the subject of massive speculation and misinformation campaigns. Journalist and former biomedical scientist Jane Qiu has gained unique access to the lab. She has interviewed the staff there extensively and tells us what she found on her visits.And Tyler Starr from the Fred Hutchinson Institute in Seattle, has looked at a range of bat coronaviruses from around the world, looking to see whether they might have the capability to jump to humans in the future. He found many more than previously thought that either have or are potentially just a few mutations away from developing this ability.Nuclear fusion researchers at the 40-year-old Joint European Torus facility near Oxford in the UK for just the 3rd time in its long history, put fully-fledged nuclear fuel, a mixture of hydrogen isotopes, into the device, and got nuclear energy out – 59 megajoules. They used a tiny amount of fuel to make this in comparison with coal or gas.A survey of Arctic waters under ice near the North pole has revealed a colony of giant sponges, feeding on fossilised worms. Deep-Sea Ecologists Autun Purser at the Alfred-Wegener-Institut and Teresa Maria Morganti from the Max Planck Institute for Marine Microbiology tells us about the discovery.Presenter: Roland Pease Producer: Julian Siddle(Image: Getty Images)

We’re 40 years into the AIDS pandemic, and even with massive public health campaigns, still, 1 ½ million become infected with HIV each year; about half that number die of its ravages. And a study just out shows that this well-understood virus can still take on more worrying forms as a new variant has been uncovered. Although the total number of cases involved is small, and the new variant is as treatable as earlier strains, the finding underlines that viruses can become more infectious and more virulent. Back in October 2020, before we had effective vaccines, 36 plucky volunteers agreed to be deliberately infected with SARS-CoV-2 in order to better understand the infection process and outcomes in what’s known as a human “challenge” trial. Dr. Chris Chiu from Imperial College reveals what they’ve learned now the results of the study are in. We’ll hear about a new plastic that’s stronger than steel and as many gardeners have long suspected, – spring-flowering has over many years been occurring earlier and earlier, at least according to a new UK study. We discuss the implications for the ecosystem. Presenter: Roland Pease Producers: Julian Siddle and Rami Tzabar(Image: 3D illustration of HIV virus. Credit: Artem Egorov/Getty Images)

There are now a number of biological indicators for the potential development of long covid. Immunologist Onur Boyman of Zurich University Hospital and Claire Steves, Clinical Senior Lecturer at King’s College London strives to tell us how pinpointing these factors is now helping in the development of strategies to predict the syndrome and prepare treatment.The James Webb telescope has reached its final orbit. The years of planning, preparation and rehearsal seem to have paid off. The telescope is now ready to begin its mission of looking back into the early universe. BBC Science correspondent Jonathan Amos has followed the mission.The widely held view that human development was propelled by our ancestors developing a taste for meat is being questioned by a new analysis of the fossil record. Paleoanthropologist Andrew Barr of George Washington University suggests part of the reason for this assumption is the sampling method, actively looking for evidence to support the hypothesis.And Michael Boudoin of Lille University has led a team of physicists who have produced the longest-lasting soap bubble ever – they managed to prevent the bubble from popping for well over a year. Presenter: Roland Pease Producer: Julian Siddle(Image credit: Horacio Villalobos/Getty Images)

The effects of the Tonga eruption could be felt around the world, many heard the boom of a sonic shock, and tsunami waves travelled far and wide. Volcanologist Shane Cronin from the University of Auckland in New Zealand is one of only a handful of people to have landed on the tiny islands above the volcano where the eruption took place. Those islands have now sunk beneath the waves but Shane tells us what he found when he went there and how his findings could inform what happens next.Stephan Grilli from the School of Ocean Engineering at the University of Rhode Island joins us from Toulon in France where he felt the effects of the shockwave and Tsunami. He says the force of the shockwave drove those waves worldwide. The oceans have continued to warm, producing continuous record temperature rises for several years now. That’s the finding of Michael Mann of the University of Pennsylvania and author of The New Climate Wars. He says warming occurred last year despite the presence of global weather patterns which would usually have a cooling effect.The long-term effects of covid-19 on health are a cause of growing concern even though in many places the virus itself now appears to be taking on a milder form. Yale University neuroscientist Serena Spudich is particularly concerned with covid’s impact on the brain. She says while the SARS- CoV-2 virus might not be found in brain cells themselves there are neurological impacts. (Image: Tonga Geological Services/via Reuters)Presenter: Roland Pease Producer: Alex Mansfield

Studies using swabs from coronavirus patients seem to contradict earlier findings from cell cultures which showed Omicon replicated faster than earlier variants. As Benjamin Meyer from the centre for Vaccinology at the University of Geneva, explains there may be other reasons why omicron is spreading faster not just how quickly it reproduces. Predicting how the pandemic will develop is not possible, however predicting what individual mutations in the virus may develop and the impact they might have individually and collectively is getting closer, Cyrus Maher and Amalio Telenti of the biotech company Vir, have developed a way to model potential future viral mutations which they hope will now be used by many scientists worldwide looking to understand the virus. There are concerns that other viruses may be on the rise, bird flu in particular, which as Nicola Lewis of the Royal Veterinary College explains is now spreading to part of the world where it is not usually seen, and infecting other animals as well as birds. And we’ve news of a massive collection of nests – at the bottom of the sea, Deep sea Ecologist Autun Perser describes how he found them in Antarctica. (Image: Getty Images)Presenter: Roland Pease Producer: Julian Siddle

Corbevax, which is being produced in India, is grown in yeast in a similar way to several other widely available vaccines. The technology used to make it is far simpler and much more readily available than that used to produce mRNA vaccines. In theory, Corbevax could be produced cheaply in large quantities to improve Covid-19 vaccine availability around the world. It was developed by a team from Baylor College of Medicine in Texas, including Maria Elena Bottazzi.Antibiotic-resistant superbugs are thought to have emerged in response to the use of antibiotics. The discovery of a superbug living on the skin of hedgehogs has challenged this view. The superbug is thought to have been living with hedgehogs long before antibiotics were discovered. Jesper and Anders Larsen at the Danish State Serum Institute in Copenhagen explain.Modifying viruses, using them to infect or kill pest organisms is an attractive proposition. However, there are concerns about what might happen when they are released, particularly over their ability to mutate and evolve, says Filippa Lentzos from Kings College Department of Global Health and Social Medicine in London.And The Royal Botanical Gardens at Kew have released the names of over 200 new species of plants and fungi discovered last year. Mycologist Tuula Niskanen and botanist Martin Cheek tell us more.(Image: Getty Images)Presenter: Roland Pease Producer: Julian Siddle