Critical Care Reviews Podcast

Pär Johansson from Copenhagen joins Rob Mac Sweeney to discuss the fascinating phase II COMBAT-COVID trial, investigating prostacyclin in intubated patients with COVID-19 and severe endotheliopathy. The trial was published in the American Journal of Respiratory and Critical Care Medicine in November 2021.

Naomi Hammond and Simon Finfer join Rob Mac Sweeney to discuss the reaction of the critical care community to the presentation and publication of both the PLUS trial and the systematic review and meta analysis comparing balanced solutions with 0.9% saline in the critically ill.

Drs Brian Driver and Matt Prekker join Rob Mac Sweeney to address some of the questions and comments that arose following the presentation and publication of the BOUGIE trial, comparing the use of a stylet with that of a bougie in emergency intubation.

Dr Rob Mac Sweeney (Belfast, Northern Ireland) chairs a panel discussion on the results of the BOUGIE trial, comparing the use of a stylet with a bougie in 1102 patients requiring emergency intubation in either the emergency department or the ICU. The panelists are Prof Jonathan Benger (Bristol, England), Dr George Kovacs (Halifax, Canada), Dr Jean-Baptiste (Nantes, France) and Prof Sheila Myatra (Mumbai, India). They are joined by the trialists Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA), Dr Brian Driver (Minneapolis, USA) & Dr Matt Semler (Nashville, USA).

Dr Chris Nutt (Belfast, Northern Ireland) asks questions posed by viewers of the BOUGIE trial results presentation livestream. These are answered by Dr Matt Semler (Nashville, USA) and Dr Brian Driver (Minneapolis, USA). Prof Jonathan Benger (Bristol, England) also joins the discussion.

Prof Sheila Myatra (Mumbai, India) delivers an independent editorial on the BOUGIE trial, comparing the use of a stylet with a bougie in 1102 patients requiring emergency intubation in the emergency department or the ICU. Dr Matt Semler (Nashville, USA) and Dr Brian Driver (Minneapolis, USA) reply to the editorial and Prof Jonathan Benger (Bristol, England) also joins the discussion.

Dr Jon Casey (Nasville, USA), Dr Stacy Trent (Denver, USA) and Dr Brian Driver (Minneapolis, USA) present the results of the BOUGIE trial at a Critical Care Reviews Trial Results Livestream, on December 8th, 2021. The BOUGIE trial compared the use of a stylet with a bougie in 1102 patients requiring emergency intubation in the emergency department or the ICU.

Theresa Olasveengen, Victoria Cornelius, and Christopher Seymour join trialists Mikael Fink Vallentin and Lars Andersen, as well as editorialist Gavin Perkins, to discuss the COCA trial. They explore the stone heart phenomenon, the use of dual analytic approaches in trials, and reflections on trial design and execution.

Dr. Nutt asks Dr. Vallentin and Andersen viewers' questions about the COCA trial. They discuss the usage, timing, and dosage of calcium in cardiac arrest, as well as the timing of adrenaline administration and the difference between IV and IO administration of calcium.

Drs Mikael Fink Vallentin and Lars Andersen present the results of the COCA trial investigating calcium for out-of-hospital cardiac arrest. They discuss the use of calcium as a potential intervention, trial methodology and results, patient outcomes, and the need for further research.