Everyday Wellness: Midlife Hormones, Health, and Science for Women 35+

I am delighted to reconnect with Dr. Anurag Singh today, the Chief Medical Officer at Timeline Nutrition. He joined me once before on Episode 268. I invited Dr. Singh back to discuss the latest research on GLP-1 agonists like Wegovy, Semaglutide, and Ozempic, which are gaining significant traction with projected sales exceeding $100 billion by 2030, potentially affecting 9% of the US population.In our conversation, we explore the contributors to our metabolic health crisis by looking at the research surrounding GLP-1 agonists, the physiology of GLP-1 peptides, and the influencing elements Dr. Singh refers to as the trifecta. We dive into the loss of muscle mass and strength, sarcopenia, and frailty associated with these drugs, and Dr. Singh shares his concerns about their impact on bone health, the gut microbiome, and their use in younger patients. We also get into lifestyle measures, mitochondrial health, hallmarks of aging, Akkermansia, and the importance of advocacy and patient empowerment. Today’s compelling and invaluable discussion with Dr. Anurag Singh highlights crucial insights into GLP-1 agonists and their broader health implications. I know it will provide significant value for our listeners.IN THIS EPISODE YOU WILL LEARN: Dr. Singh breaks down what GLP-1 agonist drugs are and how they work. How our modern-day lifestyles contribute to poor metabolic health The benefits and side-effects of using GLP-1 agonist treatments for improving metabolic health Why strength training is essential for preventing muscle loss and frailty in middle-aged women What are the potential long-term effects of SARMs on muscle mass and health? Why dietary counseling is essential for those taking GLP-1 agonist drugs The benefits of supplements for boosting mitochondrial health  Dr. Singh discusses a research study on combining lithium with GLP-1 agonists to improve the muscle quality of those with muscle-wasting conditions. Why akkermansia is essential for GLP production  Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website  Submit your questions to support@cynthiathurlow.com Connect with Dr. Anurag Singh Timeline Mitopure Email Dr. Singh: asingh@amazentis.com  Previous Episode MentionedEp. 268: Understanding the Biology of Aging with Evolved Supplementation and Nutrition, featuring Dr. Anurag Singh

Today, I am delighted to reconnect with two previous guests, Dr. Darren Candow.Dr. Candow is a distinguished professor and an internationally renowned researcher on creatine monohydrate, nutrition, and physical activity who joined me before on Episode 301, where we spoke about creatine. We are doing an AMA session today, delving into various themes surrounding creatine, from debunking outdated RDA recommendations to exploring the synergies between strength training and creatine efficacy. We look into the cognitive benefits of creatine, exploring how it interacts with caffeine and its implications for bone health, hydration, anabolic resistance, and metabolic health. I trust you will find today's AMA session as enlightening and enriching as I did while recording it.IN THIS EPISODE YOU WILL LEARN: The safety and efficacy of creatine as a supplement How creatine increases muscle mass and reduces protein catabolism The benefits of combining creatine with protein  Is it better to take creatine before or after a workout? How creatine supplementation may improve brain performance and mental clarity Why exercise is essential for those who want to experience the benefits of creatine for maintaining their bone health The benefits of resistance-band workouts for post-menopausal women Are there any age-related limits for creatine supplementation? Bio: Dr. Darren CandowDr. Darren Candow, PhD, CSEP-CEP, is Professor and Director of the Aging Muscle and Bone Health Laboratory in the Faculty of Kinesiology and Health Studies at the University of Regina, Canada. The overall objectives of Dr. Candow’s research program are to develop effective lifestyle interventions involving nutrition (primarily creatine monohydrate) and physical activity (resistance training), which have practical and clinical relevance for improving musculoskeletal aging and reducing the risk of falls and fractures. Dr. Candow has published over 120 peer-refereed journal manuscripts, supervised over 20 MSc and PhD students, and received research funding from the Canadian Institutes of Health Research, Canada Foundation for Innovation, the Saskatchewan Health Research Foundation, the National Institute of Health, and the Nutricia Research Foundation. In addition, Dr. Candow serves on the editorial review boards for the Journal of the International Society of Sports Nutrition, Nutrients, and Frontiers.Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Darren CandowOn Instagram and Twitter (now X)Previous Episode Mentioned:Ep. 301 Creatine: The Best Supplement for Better Bones & Brain Health with Darren Candow, PhD, CSEP-CEP

I am honored to have Dr. Carolyn Dean joining me today.Dr. Dean is a medical doctor, naturopath, and best-selling author. She has dedicated more than 50 years to integrating the science of medicine with the gifts of nature to help her patients feel better, boost their energy, and take control of their health.Today, our conversation centers on The Flexner Report and its influence on modern medicine and the essential role of magnesium in over 80% of metabolic functions. We dive into why we are so magnesium-depleted and common disorders associated with low magnesium levels, and we explore the effects of magnesium on bone health and the microbiome and the synergistic properties of various forms of magnesium and other micronutrients. I am confident you will find today’s discussion with Dr. Carolyn Dean as enjoyable as it is enlightening.IN THIS EPISODE YOU WILL LEARN: How the Flexner Report has impacted allopathic, functional, and integrative approaches to health and wellness Why is magnesium so poorly understood? How to get your magnesium accurately tested How our modern-day lifestyles are contributing to the current magnesium deficiency epidemic  Dr. Dean shares her formula for hydration  The potential side effects of allopathic medications and how they impact our health Why magnesium is essential for aging women The relationship between magnesium and bone health The benefits of magnesium supplementation The complex relationship between magnesium and other minerals Dr. Dean talks about Magnesium Threonate and explains how all magnesium compounds can ultimately reach the brain. Bio:Carolyn Dean, MD, ND, is a medical doctor, naturopath, and best-selling author. She has spent 50+ years committed to applying the science of medicine and the gifts of nature to help people feel better, find more energy, and take control of their personal health. Dr. Dean follows the 2017 revision of 2004's best-selling book The Magnesium Miracle® with her newest revision Magnesium: The Missing Link to Total Health®.Connect with Cynthia Thurlow    Follow on Twitter Instagram LinkedIn   Check out Cynthia’s website  Submit your questions to support@cynthiathurlow.com Connect with Dr. Carolyn Dean On her website (For educational resources) RnA ReSet Store website Podcast  Magnesium: The Missing Link to Total Health by Dr. Carolyn Dean is available on Amazon Recommended PublicationMagnesium in the Central Nervous System

I am delighted to reconnect with Dr. Dave Rabin today. He last joined me for Episode 91 in April of 2020.Dr. Rabin is a board-certified psychiatrist and neuroscientist. He is the Co-founder and CMO at Apollo Neuroscience, the first scientifically validated wearable system to improve heart rate variability, focus, and relaxation, and helps attain meditative states. He is also Co-founder and Executive Director of the Board of Medicine and a psychedelic clinical researcher, currently evaluating the mechanism of psychedelic-assisted psychotherapy and treatment-resistant illness.Today, we examine the value of touch and sensory techniques, discussing the distinctions between sympathetic and parasympathetic vagal tone in the autonomic nervous system, changes in sex hormones during perimenopause and menopause, and how that impacts sympathetic dominance, the development of stress responses, and the concept of stress leading to personal growth. We explore the influence of the vagus nerve on systemic health, explaining what HRV is and how it can demonstrate bodily coherence, and we also dive into wearable technologies like Apollo, the disruption of psychedelic interventions, and the impact of trauma on physical and mental well-being. I am confident that you will find today’s engaging discussion with Dr. Dave Rabin eye-opening and enlightening.IN THIS EPISODE YOU WILL LEARN: How touch helps us connect, bond, and support our autonomic nervous system How finding balance between the parasympathetic and sympathetic nervous systems can help us manage stress and anxiety Techniques for quickly restoring balance to the nervous system Why women experience more anxiety, depression, and heart arrhythmias during perimenopause How breathing techniques can improve heart rate variability  The significance of HRV metrics for understanding physical and mental health How the Apollo device activates a healing response within the body The potential of MDMA and other psychedelics hold for trauma healing Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Dave Rabin On his website Apollo Instagram Twitter (X) The Psychedelic Report Podcast Your Brain Explained Podcast Previous Episode MentionedEp. 91 – How To Listen To Your Body and DE-STRESS During COVID-19 – with Dr. David Rabin

Dr. Tony Youn, a renowned plastic surgeon, delves into skin aging, nutrition, and lifestyle choices in a captivating podcast conversation. Topics include collagen supplements for skin health, hormonal changes post-menopause, sunscreen selection, non-invasive fat reduction, breast implant illness, and the impact of Botox. Stay tuned for valuable insights on healthy aging and skincare support!

Today, I am thrilled to be connecting with Jillian Turecki, a renowned relationship coach, educator, author, and host of the Jillian on Love podcast. Sought out for her empathetic approach, Jillian has guided 1000s of individuals over the past two decades, driven by an unquenchable curiosity about what makes a relationship thrive. Through her compassion, directness, and authenticity, she has helped them transform their relationships with themselves by focusing on self-growth. In our conversation, we explore the societal expectations for women and how improving our relationships with ourselves allows us to become more authentic in our other relationships. We address loneliness and trauma, unlearning parental conditioning, and dealing with situationships, and get into the difference between sexual chemistry and a real connection, narcissism, and warning signs in relationships. Jillian also shares her perspective on marriage and the importance of self-reflection. Join us for the invaluable insights Jillian has drawn from her extensive experience over the past twenty years. IN THIS EPISODE YOU WILL LEARN: How women internalize narratives of weakness due to societal expectations How self-esteem impacts relationship choices What people can do to empower themselves and avoid feeling alone The benefits of self-validation What we can do to heal past wounds and foster healthy relationships The challenge of distinguishing lust from love Why self-awareness is essential within relationships Red flags to look out for in relationships How to deal with communication breakdowns in relationships Tips for moving on from a broken heart BIO:Jillian Turecki is a certified relationship coach, teacher, author, and host of the Podcast, Jillian On Love. Fueled by an insatiable curiosity about what makes a relationship thrive, Jillian has helped thousands over the last 20 years through her teachings, courses, and writing to revolutionize their relationship with themselves so that they transform their romantic relationships. Jillian is sought out for her compassionate, direct, and very authentic style of coaching, teaching, and writing.Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Jillian Turecki On her website On Instagram or Jillian On Love on Instagram Jillian On Love Podcast

I am honored to connect with Dr. Dave Diamond today.Dr. Diamond is a professor at the University of South Florida in their Department of Psychology, Molecular Pharmacology, and Physiology. He has a Ph.D. in biology, specializing in behavioral neuroscience.In our discussion today, Dr. Diamond talks about his journey as a neuroscientist and his interest in heart disease, and we discuss how Ancel Keys, the nutritional department at Harvard, and governmental dietary guidelines have significantly hindered our state of health. We explore the diet-heart hypothesis, the effects of seed oils and low-fat diets, the misconceptions surrounding cholesterol, metabolic errors, and the role of insulin resistance in coronary artery disease and metabolic health. We also scrutinize the implications of scientific misconduct, the effects of statins, and the role of nutrition in shaping lipid panels. Join us for today’s valuable, insightful, and informative conversation with Dr. Dave Diamond. IN THIS EPISODE YOU WILL LEARN: How Dr. Diamond became a leading voice in heart disease research The negative impact of a low-fat, high-carb diet  How the American Heart Association ignored the effects of sugar on heart disease How seed oils have contributed to the obesity epidemic  Why a low-carb diet could increase the risk of heart disease How the demonization of cholesterol deflects from nutritional factors exacerbating poor metabolic health How the benefits of statins get overstated  How statins can lead to strokes and heart attacks and contribute to metabolic damage The perils of scientific misconduct and the profit-driven pharmaceutical industry The benefits of a low-carb diet Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. David Diamond On X (Twitter)   Email Dr. Diamond: ddiamond@usf.edu

I am happy to connect with Coach Bronson Dant today. He has spent over a decade guiding and training people in health and fitness. He discovered the benefits of a whole food animal-based ketogenic diet for optimizing metabolic health and performance and wrote The Ultimate Ketogenic Fitness Book.In our discussion today, we dive into the powerful story of Coach Bronson’s pain-to-purpose journey. We explore the value of mindset and look at how age-related changes affect muscle, inflammation, and metabolic flexibility. He shares his three pillars of muscle health related to nutrient density, bioavailability, and satiety, and we examine the importance of sleep, the impact of extremes in exercise, and the value of stress management. We also unravel the complexities of weight loss resistance, and Coach Bronson discusses his research from the Journal of Nutrition Metabolism and Health Science, sharing his perspective on macros and functional movement in menopausal women.IN THIS EPISODE YOU WILL LEARN: Coach Bronson shares his three pillars for nutrition The limitations of basing nutrition on calories alone How the hormone piece impacts effective weight management How to avoid physical deterioration through fitness and nutrition Why Coach Bronson advocates for living life to the fullest and dying quickly How does muscle mass impact metabolic health? The importance of taking a balanced approach to weight loss How sleep aids muscle recovery and growth  Stress management, nutrition, and fitness for overall well-being How alcohol affects our health and fitness The benefits of combining functional movement training and proper nutrition for older adults  Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Bronson Dant On his website  On YouTube and Instagram The Ultimate Ketogenic Fitness Bundle is available on Amazon

I am thrilled to connect with Dr. Suzanne Gilberg-Lenz today.Dr. Gilberg-Lenz is involved in women's empowerment and public education, appearing frequently to share her expertise in women's health and integrative medicine. She received her medical degree from the USC School of Medicine and did her residency training in obstetrics and gynecology at UCLA Cedars Sinai Medical Center. She is the author of The Menopause Bootcamp. In our discussion, we dive into paradigm shifts and identity differentiation in middle age, debunking the common misconception that our worth ties into our physical attractiveness or the ability to have children. We talk about ageism and the impact of misogyny on sexual education and healthcare, exploring precursors to disease risk in menopause, pelvic floor advocacy, bone and muscle changes in menopause, and the effects of disordered eating on mental health. We also touch on brain remodeling, the three Ps, and how cycle changes can impact our ability to interact with our environment and affect our relationships. I am excited for you to listen to this insightful conversation, which is the first of two discussions with Dr. Gilberg-Lenz.IN THIS EPISODE YOU WILL LEARN: How women get pressured to conform to societal standards  Sexual health education is so important Why we need policy changes to address gender-related health disparities How our past medical history is essential for predicting our future health outcomes The importance of pelvic floor health for women The benefits of vaginal estrogen and energy-based devices during menopause  Why annual pap smears are essential for sexually active women over 40 The musculoskeletal changes that occur in menopause How disordered eating patterns often get hidden, and how they can worsen with hormonal changes and mood disorders How the brain chemistry brain of women gets remodeled with puberty, pregnancy, and menopause Bio: Dr. Suzanne Gilberg-LenzA Diplomat of the American College of Obstetrics and Gynecology, Suzanne Gilberg-Lenz, MD, received her medical degree in 1996 from the USC School of Medicine and completed her residency in obstetrics and gynecology at UCLA/Cedars-Sinai Medical Center. Dr. Gilberg-Lenz is involved in women’s empowerment and public education. She appears frequently as an expert in women’s health and integrative medicine in print, online, and on TV, where she is the Chief Medical Correspondent for the Drew Barrymore Show. She is the author of MENOPAUSE BOOTCAMP: Optimize Your Health, Empower Your Self, and Flourish as You Age (Harper Wave; October 11th) Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Dr. Suzanne Gilberg-Lenz On her website Dr. Gilberg-Lenz on Instagram The Menopause Bootcamp on Instagram Dr. Gilberg-Lenz’s Menopause Bootcamp

I am delighted to reconnect with Dr. Casey Means today.Dr. Means is the Co-founder of Levels, a health technology company dedicated to reversing the global metabolic health crisis. She is also the co-author of the book Good Energy, along with her brother Callie Means. In our discussion today, we dive into mitochondria and metabolism, looking at the impact of cognitive dissonance and the reductionistic philosophies of medical specialization. We explore the effects of siloing, the challenges posed by our broken medical system, the Flexner Report, the role of RVUs, the effects of insulin resistance on metabolic health and mitochondrial dysfunction, and the symptoms commonly seen in women. Dr. Means also offers her insights on advocacy, continuous glucose monitors, and the labs she finds impactful, and she shares the incredible story of her mother's health journey. Good Energy is an outstanding book that will benefit every listener and clinician, and I will often recommend it.IN THIS EPISODE YOU WILL LEARN: How energy gets created in the body The link between insulin resistance and acne How insulin resistance impacts fertility How underpowered parts of the brain and neurological system can show up as depression or anxiety, potentially leading to dementia The problem of our siloed, reactive, and specialist-obsessed culture The importance of getting your biomarkers tested and learning simple strategies to improve your metabolism, based on the results  What are the conditions encompassed by the metabolic spectrum disease?  The labs that Dr. Means finds most impactful Dr. Means shares her thoughts on continuous glucose monitors. The benefits of looking at your basic eating patterns in a non-judgmental and curious way before implementing any changes Dr. Means shares the powerful story of her mother’s health journey.  Bio: Dr. Casey MeansCasey Means, MD, is a Stanford-trained physician and co-founder of Levels, a health technology company with the mission of reversing the world’s metabolic health crisis. Her book on metabolic health, Good Energy, comes out in May 2024 with Penguin Random House. She received her BA with honors and MD from Stanford, was President of her Stanford class, and has served on Stanford faculty. She trained in Head & Neck Surgery before leaving traditional medicine to devote her life to tackling the root cause of why Americans are sick. She has been featured in The New York Times, The New Yorker, The Wall Street Journal, Forbes, Women’s Health, and more. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Connect with Casey Means On her website Good Energy  Newsletter signup On Instagram, Twitter, TikTok, YouTube, and LinkedIn Good Energy, by Casey and Calley Means, is available from Amazon and most anyplace good books are sold.