Explore the history and impact of smallpox, including Edward Jenner's contributions and the practice of variolation. Learn about the reach of Jenner's vaccination, its impact on the spread of smallpox, and misconceptions about the vaccine. Hear stories of working in a smallpox outbreak and strategies for containment. Understand the challenges of eradicating smallpox and the importance of targeting the disease.

Allon Bloch, Co-founder and CEO of K Health, discusses using AI to improve the doctor-patient experience. Topics include the development of a predictive engine, online access to healthcare, challenges and advantages of online systems, integration of a language model for patient engagement, and insights in the used car business.

Sonia Kastner, founder and CEO of Pano, discusses using data and machine learning to detect and locate wildfires. The podcast explores the challenges of training AI models with smoke-like scenarios and the high costs of running AI experiments. It also highlights the importance of data in disaster management and supply chains.

Amit Sharma, the founder and CEO of Narvar, discusses the challenges of offering free returns and whether retailers can afford them. They explore the evolution of online returns, the value proposition of companies, and the future of returns in a changing economic landscape. They argue for a more transparent conversation about return costs and propose that customers should bear the cost to create a fairer system. The chapter also shares valuable insights from their experiences at Apple and Walmart.

Danielle Feinberg, Visual Effects Supervisor at Pixar Animation Studios, discusses optimizing technology for creativity. She shares insights on the role of director of photography at Pixar, innovative lighting techniques, and the impact of technological advancements on creative storytelling in computer animated films. She also shares her experiences as the only woman in a room full of men at work.

Yaron Singer is the founder and CEO of Robust Intelligence. Yaron’s problem is this: How do you reduce AI’s security and reliability risks? Yaron was a computer science professor at Harvard and worked at Google before starting Robust Intelligence. The company’s software tests AI models and datasets for problems with performance and security.See omnystudio.com/listener for privacy information.

Chris Monroe is the co-founder and chief scientist of IonQ. Chris’s problem is this: How do you build a quantum computer that will actually work? Quantum computing has the potential to transform fields from drug development to clean energy to cybersecurity, but so far no one has been able to build a quantum computer that can reliably outperform existing computers. Monroe is also a physics professor at Duke University, and he talks Jacob through the principles that make quantum computing possible.See omnystudio.com/listener for privacy information.

Seven stocks are powering the market: Alphabet, Amazon, Apple, Meta, Microsoft, Nvidia and Tesla. How will they do in the second half of this year? Ethan Wu hosts as Rob ‘Value This’ Armstrong takes on Elaine ‘The Lex Flex’ Moore. In three rounds they pick their winners for the second half of 2023, and tell us why they chose them. If you enjoyed this preview of the new podcast Unhedged, subscribe to the show now: https://apple.co/478A3VSSee omnystudio.com/listener for privacy information.

Charles Fisher is the co-founder and CEO of Unlearn AI. Charles’ problem is this: How do you build an AI model that can predict human health? Charles and his colleagues have built a predictive model of health that is already being used in clinical trials, and might one day be deployed to predict individuals’ health outcomes.See omnystudio.com/listener for privacy information.

Laura Modi is the founder and CEO of Bobbie, a company that makes baby formula and sells it directly to parents. Laura’s problem is this: how do you launch a startup in a highly regulated industry that has pretty much been a duopoly for decades? Part of Laura’s answer is marketing, which raises another question: how do you get people to consider formula despite so much messaging that breastfeeding is better?See omnystudio.com/listener for privacy information.