The Energy Balance Podcast

In this episode we discuss: How you can induce mitochondrial biogenesis and uncoupling without stress Why you want tighter mitochondrial coupling if you want to induce uncoupling in a healthy way The difference between reactive oxygen species production in a high energy state versus a low energy state How many supposedly hormetic interventions, like exercise, fasting, and ketogenic diets, can be beneficial despite the stress they cause rather than because of it How the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view What anti-hormesis looks like in a practical sense   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-78-why-maximizing-energy-production-and-minimizing-stress-is-optimal-for-health-hormesis-part-4/    Timestamps: 3:22 – the difference between producing ROS in a high energy state compared to a low energy state   9:38 – how ATP protects against oxidative stress 21:55 – how CO2 protects against oxidative stress 26:31 – how tighter mitochondrial coupling is better for inducing uncoupling 27:48 – the broader context of why we want to adapt to a high-energy, low-stress state  33:28 – how exercise can be beneficial despite the stress it causes, rather than because of it 47:06 – how low-carb/ketogenic diets can be beneficial despite the stress they cause, rather than because of it 57:40 – what to expect when moving away from a hormetic approach  1:02:16 – how the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view  1:03:39 – what anti-hormesis looks like in a practical sense  

In this episode we discuss: Why the stress caused by calorie restriction, exercise, cold thermogenesis, fasting, ketogenic diets, Wim Hoff breathing, and supplements like resveratrol is not supportive of our health Why autophagy, mitochondrial biogenesis, and uncoupling are not always beneficial Whether being tolerant to stress is a sign of health Why it’s virtually impossible to apply hormesis in a practical sense The difference between reactive oxygen species production in a high energy state versus a low energy state   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-77-why-you-dont-want-to-force-autophagy-mitochondrial-biogenesis-uncoupling-hormesis-part-3/    Timestamps: 3:27 – why reductions in adaptive responses in degenerative states and the benefits of “hormetic” interventions does not lend support to hormesis 13:49 – why improving tolerance to stress is not inherently beneficial and the cost of stress across generations 28:58 – how the fact that stress is cumulative throws a wrench in the idea of hormesis   37:05 –the difference between producing ROS in a high energy state versus a low energy state 49:16 – the low energy, high ROS state is a feature of degenerative conditions  

In this episode we discuss: How the largest body of evidence cited in favor of hormesis actually doesn’t support it at all Why caloric restriction is NOT responsible for slowing aging and extending lifespan (and what is actually responsible) The many factors that confound the calorie restriction research (including differences between organisms, poor research design, amino acid restriction, PUFA, endotoxin, and more)   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-76-why-caloric-restriction-is-not-responsible-for-lifespan-extension-hormesis-part-2/    Timestamps: 3:36 – the physiology of hormesis and the general support for hormesis 12:54 – outlining the problems with hormesis 18:51 – how differences between organisms confound the caloric restriction research  37:34 – the problem with using proxy markers to evaluate health effects and the importance of context 48:20 – how differences between organisms confound the caloric restriction research (cont.) 51:58 – how hydration status and macronutrient ratios confound the caloric restriction research 55:57 – how the myopic hormetic view leads to the ignorance of many confounding variables 1:02:00 – how the restriction of particular amino acids, ad libitum feeding, and a refined diet confound the caloric restriction research 1:11:58 – how PUFA confounds the caloric restriction research 1:30:09  – how endotoxin and gut health confound the caloric restriction research  

In this episode we discuss: How the concept of hormesis defends our exposure to toxic chemicals, industrial contaminants and pollutants, and ionizing radiation Why hormesis is a dangerous, anti-scientific idea masquerading as science The suspicious history of hormesis and its current definitional problems  The important distinction between stress and adaption The problems with the terms “eustress” and “distress”    Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-75-hormesis-as-an-anti-scientific-defense-for-industrial-pollution-and-chemical-exposure-hormesis-part-1/    Timestamps: 3:36 – an introduction to hormesis as a means to reverse aging and reverse chronic health conditions  6:45 – what is hormesis 12:34 – the suspicious history of hormesis   16:20 – the definitional problems with hormesis 34:51 – how hormesis is influencing dangerous public health policies 47:35 – the difference between stressor effects and specific effects, creating a distinction between stress and adaptation, and the problems with the terms “eustress” and “distress”  

In this episode we discuss: Why low-carb diets are inherently stressful How carbohydrates oppose stress and decrease the stress hormones Why carbohydrates ARE essential and why their intake plays a vital role in our endocrine systems   Whether most people have hypothyroidism and how carnivore diets can cause hypothyroidism Why carnivore diets are NOT ideal for gut health even if they improve symptoms in the short-term  The real reason why people are moving from a carnivore diet to a “Ray Peat Diet”   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-74-refuting-nutrition-with-judys-thoughts-on-the-ray-peat-diet-part-2/    Timestamps: 3:03 – why low-carb diets drive physiological stress and carbohydrates oppose stress 21:51 – why carbohydrates are essential and why our endocrine systems are so tightly tuned to carbohydrate intake 29:19 – do most people have hypothyroidism? 44:38 – is hypothyroidism ever the root problem? 53:28 – how carnivore diets can cause hypothyroidism 1:01:36 – whether taking exogenous steroid hormones (like pregnenolone or progesterone) will increase cortisol 1:12:19 – should we focus on gut health over thyroid health? 1:23:31 – why are people really moving from carnivore to a “Ray Peat Diet?”

In this episode we discuss: Why our brains favor glucose as their fuel source Why fat is less energetically favorable as a fuel compared to carbohydrates   The problem with reducing the bioenergetic view to the “Ray Peat diet”   The amount of carbohydrates our bodies can handle before storing them as fat Whether consuming carbohydrates causes Alzheimer’s disease  Whether the raising of our blood sugar and the production of insulin is wasteful and harmful   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-73-refuting-nutrition-with-judys-thoughts-on-the-ray-peat-diet-part-1/    Timestamps: 3:01 – an introduction to Nutrition With Judy’s article on Ray Peat 7:41 – energy and metabolism are at the core of the bioenergetic view 18:43 – the problem with reducing the bioenergetic paradigm to the “Ray Peat diet” and the importance of context 29:28 – why carbohydrate oxidation is more energetically favorable to fat oxidation 41:09 – why consuming carbohydrates does not make you fat or prevent you from oxidizing fat 45:35 – our body’s impressive capacity for carbohydrate oxidation and storage 58:06 – glucose requirements in the brain other than energy production 1:00:21 – why the increased production of CO2 from carbohydrate oxidation further supports the energy favorability of carbohydrates 1:00:58 – does consuming carbohydrates cause Alzheimer’s disease? 1:06:05 – why the raising of blood sugar and the production of insulin is not wasteful or harmful  

In this episode we discuss: Which vitamins and minerals are most relevant to dental health How our gut health and microbiome can affect oral health  How to prevent potential dental harm on a high-sugar diet/from consuming fruits and other sugar-containing foods   How to determine the order of operations for making lifestyle adjustments  The first step to addressing virtually all health issues   Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-72-dental-health-on-a-high-sugar-diet-how-to-determine-whats-blocking-energy-production-q-a/    Timestamps: 2:49 – factors to consider for supporting dental health and preventing tooth erosion and decay 23:10 – how to determine the order with which to address different aspects of health to address first and how to determine what’s blocking our energy production  

In this episode we discuss: How much weight gain can be attributed to increases in glycogen storage when adding in carbohydrates At what point weight gain would be a sign of an underlying metabolic issue The best ways to get calcium if you’re not eating dairy   Potential ways to improve your tolerance to dairy The best form of calcium to use as a calcium supplement  Which calcium-containing vegetables might be worth including in your diet    Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-71-weight-gain-from-replenishing-glycogen-calcium-sources-other-than-dairy-q-a/    Timestamps: 3:13 – how much weight gain can be attributed to refilling glycogen 25:02 – calcium sources other than dairy  

In this episode we discuss: The optimal amount of exercise for fatty liver disease  How stress impacts fatty liver disease and basic ways to reduce stress  Supplements that help the liver clear fat to reverse fatty liver  The best supplements for raising metabolism to reverse fatty liver disease  Supplements that reduce inflammation and oxidative stress in fatty liver disease    Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-70-pro-metabolic-supplements-for-fatty-liver-disease-nafld-part-8/   Timestamps: 2:57 – the importance of exercise/movement and not being sedentary for fatty liver disease 8:58 – the impact of stress on fatty liver disease and basic ways to reduce stress 16:31 – the best choline supplement for fatty liver disease and when it makes sense to supplement choline or methionine 26:40 – B vitamins for fatty liver disease 32:40 – taurine and TUDCA for fatty liver disease 41:36 – glycine for fatty liver disease 48:52 – essential amino acids for fatty liver disease 50:42 – theanine and tea for fatty liver disease 52:36 – vitamin E and vitamin C for fatty liver disease 57:35 – aspirin for fatty liver disease 1:00:00 – lactoferrin for fatty liver disease 1:03:10 – antimicrobials for fatty liver disease 1:05:23 – caffeine and coffee for fatty liver disease 1:09:43 – inosine for fatty liver disease 1:11:00 – the impact of thyroid hormones on fatty liver disease 1:20:24 – testosterone and other steroid hormones for fatty liver disease  

In this episode we discuss: How carbohydrate deficiencies can drive fatty liver disease The particular type of fat you’ll want to avoid if you have fatty liver disease The optimal amount of protein, fat, and carbs for reversing fatty liver disease The order of dietary adjustments for fatty liver disease and why this matters Whether reducing fructose intake is necessary for treating or reversing fatty liver disease    Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy   Click here to check out the show notes: https://jayfeldmanwellness.com/ep-69-carb-deficiencies-saturated-fat-intake-the-best-diet-for-fatty-liver-nafld-part-7/    Timestamps: 3:38 – the importance of dietary protein and choline for fatty liver 14:41 – the best types of fats and how much of these fats to eat for fatty liver 28:30 – the ideal carbohydrate sources for reversing fatty liver and major considerations to keep in mind 40:43 – the importance of experimentation when implementing dietary changes 47:05 – why carbohydrates are so effective at opposing stress, increasing metabolism, and reducing oxidative stress 49:22 – the importance of nutrient density and particular micronutrients for fatty liver disease 52:56 – why it’s important to minimize alcohol intake in fatty liver disease and how to protect against the effects of alcohol on the liver 56:12 – how diet, lifestyle, and supplements fit together to create a holistic approach to treating or reversing fatty liver