Ep. 78: Why Maximizing Energy Production and Minimizing Stress Is Optimal For Health (Hormesis Part 4)

• How you can induce mitochondrial biogenesis and uncoupling without stress

• Why you want tighter mitochondrial coupling if you want to induce uncoupling in a healthy way

• The difference between reactive oxygen species production in a high energy state versus a low energy state

• How many supposedly hormetic interventions, like exercise, fasting, and ketogenic diets, can be beneficial despite the stress they cause rather than because of it

• How the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view

• What anti-hormesis looks like in a practical sense

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Click here to check out the show notes: https://jayfeldmanwellness.com/ep-78-why-maximizing-energy-production-and-minimizing-stress-is-optimal-for-health-hormesis-part-4/ 

Timestamps:

3:22 – the difference between producing ROS in a high energy state compared to a low energy state  

9:38 – how ATP protects against oxidative stress

21:55 – how CO2 protects against oxidative stress

26:31 – how tighter mitochondrial coupling is better for inducing uncoupling

27:48 – the broader context of why we want to adapt to a high-energy, low-stress state 

33:28 – how exercise can be beneficial despite the stress it causes, rather than because of it

47:06 – how low-carb/ketogenic diets can be beneficial despite the stress they cause, rather than because of it

57:40 – what to expect when moving away from a hormetic approach 

1:02:16 – how the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view 

1:03:39 – what anti-hormesis looks like in a practical sense