Ep. 76: Why Caloric Restriction Is NOT Responsible For Lifespan Extension (Hormesis Part 2)

• How the largest body of evidence cited in favor of hormesis actually doesn’t support it at all

• Why caloric restriction is NOT responsible for slowing aging and extending lifespan (and what is actually responsible)

• The many factors that confound the calorie restriction research (including differences between organisms, poor research design, amino acid restriction, PUFA, endotoxin, and more)

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Click here to check out the show notes: https://jayfeldmanwellness.com/ep-76-why-caloric-restriction-is-not-responsible-for-lifespan-extension-hormesis-part-2/ 

Timestamps:

3:36 – the physiology of hormesis and the general support for hormesis

12:54 – outlining the problems with hormesis

18:51 – how differences between organisms confound the caloric restriction research 

37:34 – the problem with using proxy markers to evaluate health effects and the importance of context

48:20 – how differences between organisms confound the caloric restriction research (cont.)

51:58 – how hydration status and macronutrient ratios confound the caloric restriction research

55:57 – how the myopic hormetic view leads to the ignorance of many confounding variables

1:02:00 – how the restriction of particular amino acids, ad libitum feeding, and a refined diet confound the caloric restriction research

1:11:58 – how PUFA confounds the caloric restriction research

1:30:09  – how endotoxin and gut health confound the caloric restriction research