For the first time ever we’ve used CRISPR  to edit someone’s genes INSIDE THEIR BODY! So far we’ve been able to reverse some effects of rare genetic eye disease that results in blindness, and this is only the beginning! You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth References & Further Reading https://medlineplus.gov/genetics/condition/leber-congenital-amaurosis/ https://rarediseases.info.nih.gov/diseases/634/leber-congenital-amaurosis https://luxturna.com Gene Therapy https://www.nature.com/articles/d41586-018-06195-6 https://www.nature.com/articles/s41587-020-0493-4 https://www.nature.com/articles/s41573-019-0012-9 The EDIT-101 Trial https://clinicaltrials.gov/ct2/show/study/NCT03872479 https://www.nature.com/articles/s41591-018-0327-9 https://text.npr.org/2021/09/29/1040879179/vision-loss-crispr-treatment https://www.nature.com/articles/d41586-020-00655-8https://www.nature.com/articles/d41586-020-00655-8 https://jamanetwork.com/journals/jama/fullarticle/2764428https://jamanetwork.com/journals/jama/fullarticle/2764428

In this spooky episode of Sci Guys we explore the life of Johann Konrad Dippel - a mad scientist that some credit as the inspiration for Mary Shelley’s Dr Frankenstein… Despite the pack of any evidence. You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth References & Further Reading Johann Konrad Dippel https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1034731/?page=5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1034731/?page=5 https://publishing.rcseng.ac.uk/doi/pdf/10.1308/147363513X13500508916973 Alchemy & Frankenstein https://www.britannica.com/topic/alchemy/Modern-alchemy https://www.britannica.com/topic/Frankenstein

You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth References & Further Reading Scientific Studies & Papers https://www.science.org/lookup/doi/10.1126/science.1250830 https://www.sciencedirect.com/science/article/abs/pii/S0165178116301524?via%3Dihub https://journals.sagepub.com/doi/10.1177/0963721419884309 News & Magazine Articles https://www.bbc.com/news/science-environment-28130690.amp https://www.scientificamerican.com/article/why-boredom-is-anything-but-boring/ https://www.newyorker.com/culture/annals-of-inquiry/what-does-boredom-do-to-us-and-for-us

Can trees talk to each other? It turns out they might be able to, using fungi… This week, we discuss the Wood Wide Web that most of the world’s plants use to help them survive! You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth References & Further Reading Fungi https://www.livescience.com/amp/53618-fungus.html https://www.britannica.com/science/fungus/Mycorrhiza Plants https://www.britannica.com/plant/tree https://www.britannica.com/science/forest Mycorrhizal Networks https://www.sciencedirect.com/science/article/pii/B9780123739445003278 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802747/ https://www.bbc.com/news/science-environment-48257315.amp https://www.nature.com/articles/449136a https://www.science.org/content/article/wood-wide-web-underground-network-microbes-connects-trees-mapped-first-time https://www.smithsonianmag.com/science-nature/the-whispering-trees-180968084/ https://www.sciencefocus.com/nature/mycorrhizal-networks-wood-wide-web/amp/ https://www.nationalforests.org/blog/underground-mycorrhizal-network https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/mycorrhizae

Uterus transplants are on the verge of becoming a common surgery for cis women, but one of the first women to ever receive this kind of surgery wasn’t cis… The life of Lilli Elbe, one of the first women to receive gender affirming surgery, has been romanticised and repackaged as a tender tragedy - but her real story is far more interesting & upliftng. You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth References & Further Reading Transplants https://www.britannica.com/science/transplant-surgery/Organ-transplants https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778785/ https://www.nhsbt.nhs.uk/who-we-are/a-history-of-donation-transfusion-and-transplantation/ Uterus Transplants https://academic.oup.com/humupd/article/3/3/267/653944https://www.britannica.com/science/uterus https://pubmed.ncbi.nlm.nih.gov/29210893/ https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0037-1606321.pdf https://timesofmalta.com/articles/view/turkish-woman-has-world-s-first-womb-transplant.388596 https://www.abc.net.au/news/2014-10-04/woman-has-baby-after-womb-transplant-in-sweden/5790726?nw=0&r=HtmlFragment https://www.bbc.co.uk/news/av/health-29516910https://time.com/5044565/exclusive-first-u-s-baby-born-after-a-uterus-transplant/ https://www.nytimes.com/2016/04/09/health/yeast-infectionled-to-removal-of-transplanted-uterus.html?_r=0 https://jamanetwork.com/journals/jamasurgery/article-abstract/564280 https://obgyn.onlinelibrary.wiley.com/doi/full/10.3109/00016349.2010.520688 https://onlinelibrary.wiley.com/doi/10.1111/j.1432-2277.2012.01438.x https://www.nytimes.com/2002/03/07/world/medical-first-a-transplant-of-a-uterus.html Uterus Transplants for Trans Women https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2775302 https://jme.bmj.com/content/45/10/687.full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492192/ Lilli Elbe https://www.britannica.com/biography/Lili-Elbe https://www.biography.com/artist/lili-elbe

What would you do if you found an animal that, with a little help, could potentially live forever? Worship it as a God? What could go wrong? That’s exactly what we’re digging into this week! You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod References & Further Reading Lobsters https://www.britannica.com/animal/lobster https://www.smithsonianmag.com/science-nature/dont-listen-to-the-buzz-lobsters-arent-actually-immortal-88450872/ Immortality & Aging https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370421/ https://www.science.org.au/curious/earth-environment/animals-can-live-forever Lobster Cult https://www.urbo.com/content/your-new-god-worshiping-a-facebook-group-lobster/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748990/ https://www.leviathanlobstergod.com/about

Buckminster Fuller was a futurist and inventor with a silly name and a penchant for creating incredible inventions - from cars, to homes, to geodesic domes! You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod References & Further Reading References & Further Reading https://youtu.be/N1yxFDvqALI https://www.britannica.com/biography/R-Buckminster-Fuller https://www.bfi.org/about-fuller/big-ideas/dymaxion-world/dymaxion-map https://www.britannica.com/technology/geodesic-dome https://www.wired.com/2016/03/buckminster-fuller-brilliant-crank-lot-teach-silicon-valley/amp https://amp.theguardian.com/theguardian/2013/jul/04/buckminster-fuller-architecture-design https://library.stanford.edu/spc/manuscripts-division/r-buckminster-fuller-timeline https://www.nytimes.com/1983/07/03/obituaries/r-buckminster-fuller-futurist-inventor-dies-at-87.html https://exhibits.stanford.edu/bucky/feature/what-is-a-geodesic-dome https://www.bfi.org/about-fuller/big-ideas/geodesic-domes

Do you ever have a thought come to mind that doesn’t feel like something you’d think, a thought that can make you feel disgusted or uneasy? Those are intrusive thoughts, and while they’re strongly associated with mental illness, they might be a bit more common than you might think… You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod References & Further Reading https://www.nhs.uk/mental-health/conditions/obsessive-compulsive-disorder-ocd/symptoms/ https://www.cam.ac.uk/research/news/scientists-identify-mechanism-that-helps-us-inhibit-unwanted-thoughts https://www.sciencedirect.com/science/article/abs/pii/S2211364913000675 https://www.livescience.com/amp/44687-most-people-have-unwanted-thoughts.html https://www.mind.org.uk/information-support/your-stories/dealing-with-intrusive-thoughts/ https://pubmed.ncbi.nlm.nih.gov/28776482/ https://pubmed.ncbi.nlm.nih.gov/27510608/ https://www.researchgate.net/journal/Journal-of-Obsessive-Compulsive-and-Related-Disorders-2211-3649 https://psycnet.apa.org/record/2014-33292-013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834572/ Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth

American History tends to ignore the achievements of black people - which is why you probably haven’t heard of Benjamin Banneker… He was a polymath who went verbally toe to toe with Thomas Jefferson on the topic of slavery, was instrumental in the creation of the capital, and did so much more! You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod References & Further Reading https://www.whitehousehistory.org/benjamin-banneker https://archive.org/details/bulletinunitedst2311964unit/page/17/mode/1up?view=theater https://www.smithsonianmag.com/smart-news/three-things-know-about-astronomer-benjamin-bannekers-pioneering-career-180967136/ https://friendsofbenjaminbanneker.com/history/benjamin-banneker-2/ https://books.google.co.uk/books?id=2vEQAQAAMAAJ&pg=PA65&redir_esc=y#v=onepage&q&f=false https://www.history.com/.amp/news/cicadas-discovery-benjamin-banneker https://babel.hathitrust.org/cgi/pt?id=uiug.30112037299119&view=1up&seq=13&skin=2021 https://www.biography.com/.amp/scientist/benjamin-banneker https://www.mentalfloss.com/article/85984/retrobituaries-benjamin-banneker-african-american-mathematician-who-may-have-saved https://www.britannica.com/biography/Benjamin-Banneker https://www.wired.com/2010/02/benjamin-banneker-the-first-african-american-geek/am Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth

At the end of WWII hundreds of uranium cubes made for the Nazi nuclear program were taken by the USA, but they didn't take them all. Quite a number of these nuclear cubes went missing... A few have popped up here and there, until recently it's always been near impossible to tell if a cube is real, or just a really good replica - but scientists have just found a wild new way to find which ones are fakes... You can WATCH the podcast over on our YouTube channel: http://youtube.com/SciGuys Help keep the show running by supporting us on Patreon! http://patreon.com/sciguys If you'd like to see more of us, follow our socials! Facebook http://facebook.com/SciGuysPod Twitter http://twitter.com/SciGuysPod Instagram http://instagram.com/SciGuysPod References & Further Reading https://www.google.co.uk/amp/s/news.sky.com/story/amp/hundreds-of-cubes-of-nazi-uranium-are-missing-now-scientists-have-a-new-way-to-spot-them-12389326 https://www.washingtonpost.com/gdpr-consent/?next_url=https%3a%2f%2fwww.washingtonpost.com%2fhistory%2f2021%2f08%2f25%2fnazi-nuclear-program-failed-uranium-cube%2f https://www.newscientist.com/article/2287673-investigation-of-nazi-uranium-could-help-stop-modern-nuclear-smuggling/amp/?__twitter_impression=true https://www.history.com/.amp/news/wwii-nazi-atomic-secrets-alsos-mission-kidnap-heisenberg https://www.britannica.com/science/nuclear-fission https://science.howstuffworks.com/nuclear-bomb.htm https://www.osti.gov/biblio/1321436 https://www.britannica.com/science/carbon-14-dating https://www.britannica.com/science/hydrogen/Isotopes-of-hydrogen#ref621366 https://www.britannica.com/biography/Werner-Heisenberg/Heisenberg-and-the-Nazi-Party Follow the SCI GUYS @notcorry / @jampkin / @lukecutforth