Comedian W. Kamau Bell and Conan O’Brien discuss the weapons they keep at home, the best YouTube video essays, working on What Would You Do?, and gaining notoriety with Denzel Washington. Conan also humorously navigates his team’s various incapacitations.

Conan chats with Brie, a mother of six sons post-Mormon, discussing her experiences with coffee and alcohol. They also talk about Brie owning a bridal shop and even designing a bridal gown with Conan.

Comedy legend Carol Burnett joins Conan O’Brien to discuss comedic arts, tales from her show, meeting Lucille Ball, and making friends on set. Conan recalls his early career days, engaging in banter and humorous anecdotes before wrapping up with podcast production details.

Conan chats with Brandon, a paranormal investigator, about spooky destinations, Conan's haunting style, equipment used in investigations, and funny ghost-busting experiences. They also discuss a seafaring adventure, mobile connectivity, and a chilling encounter at the Screaming Tunnel near Niagara Falls.

Kristen Wiig discusses sketch comedy, favorite characters, and her new series with Conan. They joke about listener theories, her journey to stardom, navigating comedy transitions, and the project 'Pomerayal'. The hosts talk about greeting dogs before humans, sponsored segments, and a comical dialogue about giving birth in a recording studio.

Conan chats with a sex therapist about spicing up the bedroom, the challenges of introducing a third party, and the importance of communication in relationships. The podcast explores cultural differences in discussing intimate matters openly and highlights the complexities of sexual dynamics and satisfaction.

Jon Bon Jovi joins Conan O’Brien to chat about his new documentary, performing with Bruce Springsteen, and wanting to leave a legacy. They also discuss Muppets, senior sex lives, and take audience questions.

Conan chats with an escape room Game Master about various escape room themes and player dynamics, creativity in show business-related projects, Dungeons and Dragons adventures, and the humorous tale of Filonius Stumpleton. They also touch on time management, therapy benefits, and online therapy services.

Zach Woods discusses why being smart is overrated, his new animated series, getting hooked on jazz, and unintentional oversharing with Conan. Plus, a hilarious arm-wrestling contest and banter between the two friends.

Businesswoman Melinda French Gates talks about her journey into computer science, philanthropy, and importance of education. The podcast also includes discussions on Gates Foundation letters, planning a Carnival Cruise Line vacation, prioritizing well-being, and empowering children in wealthy environments.